A5D6T3 · A5D6T3_DANRE
- Proteinprotein-tyrosine-phosphatase
- Geneptpn22
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids887 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | non-membrane spanning protein tyrosine phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | heart development | |
Biological Process | negative regulation of T cell activation | |
Biological Process | T cell receptor signaling pathway |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameprotein-tyrosine-phosphatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA5D6T3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-294 | Tyrosine-protein phosphatase | ||||
Sequence: FAGEFLKLKRQSTKYRAERTYPTTAADKQDNVKKNRYKDIVPFDHSRVKLSLFTSKNDTDYINASFIKGVSGSKAYIATQGPLSNTVLDFWRMIWEYNIQVIVMVCREFEMGRKKCERYWPESKGDVFVCEAFTILYESDENKGDYLTRTLKVTFKQESRRLKQLHYVNWPDHGVPDSIPAILELLQEMRIYQDNEEIPICIHCSAGCGRTGALCAIDYTWNLLKRQIIPEDFSIFELVKGMRTQRPSVVQTKEQYELVYRTIKLL | ||||||
Domain | 211-285 | Tyrosine specific protein phosphatases | ||||
Sequence: LELLQEMRIYQDNEEIPICIHCSAGCGRTGALCAIDYTWNLLKRQIIPEDFSIFELVKGMRTQRPSVVQTKEQYE | ||||||
Region | 306-338 | Disordered | ||||
Sequence: SNKVPDSSSPAMLSSGSELSDISDFSDQEQTEH | ||||||
Compositional bias | 307-329 | Polar residues | ||||
Sequence: NKVPDSSSPAMLSSGSELSDISD | ||||||
Compositional bias | 506-524 | Polar residues | ||||
Sequence: MPKHDSNNKGGNTLSSDEE | ||||||
Region | 506-535 | Disordered | ||||
Sequence: MPKHDSNNKGGNTLSSDEESPPPLPERTPE | ||||||
Region | 564-584 | Disordered | ||||
Sequence: TSTSSESVNRDNPPSPVPPLP | ||||||
Region | 683-705 | Disordered | ||||
Sequence: SHGQTFNSFQGKESLTPPLPERT | ||||||
Region | 720-771 | Disordered | ||||
Sequence: SAPCQPVEAEQYRGRVGTSSEWSGTSQPKSSVAHTWSRSKSVRAKGSKQEPL | ||||||
Compositional bias | 735-761 | Polar residues | ||||
Sequence: VGTSSEWSGTSQPKSSVAHTWSRSKSV | ||||||
Compositional bias | 802-824 | Polar residues | ||||
Sequence: ATGQLENQSNKGAEKTSLVSKAR | ||||||
Region | 802-863 | Disordered | ||||
Sequence: ATGQLENQSNKGAEKTSLVSKARSKSFKLLKGKQKPKTAPPPVPSSASSTAPPQPVPTYGPV | ||||||
Compositional bias | 838-860 | Pro residues | ||||
Sequence: KTAPPPVPSSASSTAPPQPVPTY | ||||||
Region | 868-887 | Disordered | ||||
Sequence: SFGTRFGKPKGPRNKPETWV |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length887
- Mass (Da)98,908
- Last updated2007-06-12 v1
- Checksum15979A43E969A5CB
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2B909 | A0A8M2B909_DANRE | ptpn22 | 886 | ||
A0A8M2B913 | A0A8M2B913_DANRE | ptpn22 | 882 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 307-329 | Polar residues | ||||
Sequence: NKVPDSSSPAMLSSGSELSDISD | ||||||
Compositional bias | 506-524 | Polar residues | ||||
Sequence: MPKHDSNNKGGNTLSSDEE | ||||||
Compositional bias | 735-761 | Polar residues | ||||
Sequence: VGTSSEWSGTSQPKSSVAHTWSRSKSV | ||||||
Compositional bias | 802-824 | Polar residues | ||||
Sequence: ATGQLENQSNKGAEKTSLVSKAR | ||||||
Compositional bias | 838-860 | Pro residues | ||||
Sequence: KTAPPPVPSSASSTAPPQPVPTY |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC139874 EMBL· GenBank· DDBJ | AAI39875.1 EMBL· GenBank· DDBJ | mRNA |