A5D6T3 · A5D6T3_DANRE

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionnon-membrane spanning protein tyrosine phosphatase activity
Molecular Functionprotein tyrosine phosphatase activity
Biological Processheart development
Biological Processnegative regulation of T cell activation
Biological ProcessT cell receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    protein-tyrosine-phosphatase
  • EC number

Gene names

    • Name
      ptpn22
    • Synonyms
      ptpn12
      , si:dkey-78k11.1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A5D6T3

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain29-294Tyrosine-protein phosphatase
Domain211-285Tyrosine specific protein phosphatases
Region306-338Disordered
Compositional bias307-329Polar residues
Compositional bias506-524Polar residues
Region506-535Disordered
Region564-584Disordered
Region683-705Disordered
Region720-771Disordered
Compositional bias735-761Polar residues
Compositional bias802-824Polar residues
Region802-863Disordered
Compositional bias838-860Pro residues
Region868-887Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    887
  • Mass (Da)
    98,908
  • Last updated
    2007-06-12 v1
  • Checksum
    15979A43E969A5CB
MDAQTHILRNQLDLIAIKEAEDETAENGFAGEFLKLKRQSTKYRAERTYPTTAADKQDNVKKNRYKDIVPFDHSRVKLSLFTSKNDTDYINASFIKGVSGSKAYIATQGPLSNTVLDFWRMIWEYNIQVIVMVCREFEMGRKKCERYWPESKGDVFVCEAFTILYESDENKGDYLTRTLKVTFKQESRRLKQLHYVNWPDHGVPDSIPAILELLQEMRIYQDNEEIPICIHCSAGCGRTGALCAIDYTWNLLKRQIIPEDFSIFELVKGMRTQRPSVVQTKEQYELVYRTIKLLFERYLAALEAPSNKVPDSSSPAMLSSGSELSDISDFSDQEQTEHRNDEIRVDEYNHVMQNSASWQQPHSQTFSPEVMSNKLTPADLHNARCEWVQITDQSSSIAPVLQTDFTTCGSQKPEASTSLSTTSTQVSCSNYLEWVENQEASPVVKDHNTVIPSTLCLTVEDPYFGPESPPGSNNPSVLNCTAHEIWTEKPCFTIPSLALNNQALEMPKHDSNNKGGNTLSSDEESPPPLPERTPESFIMADETSGQSNNEKSETSELLTLVIPTSTSSESVNRDNPPSPVPPLPERTPESFEMAMDADLVQNVTQEKPQEVVMRVGKSLEWSGQTNEGQTDMKRSWSRSKSLKLRMSLPASSTPLSPITITSHSPPPLLYKHTQDTFLDTSTSHGQTFNSFQGKESLTPPLPERTPESFILHTEKVSNNSAPCQPVEAEQYRGRVGTSSEWSGTSQPKSSVAHTWSRSKSVRAKGSKQEPLSVAPLSLPVSVTTPTIGQVEHQMGYSNQLAATGQLENQSNKGAEKTSLVSKARSKSFKLLKGKQKPKTAPPPVPSSASSTAPPQPVPTYGPVGLLFSFGTRFGKPKGPRNKPETWV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M2B909A0A8M2B909_DANREptpn22886
A0A8M2B913A0A8M2B913_DANREptpn22882

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias307-329Polar residues
Compositional bias506-524Polar residues
Compositional bias735-761Polar residues
Compositional bias802-824Polar residues
Compositional bias838-860Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC139874
EMBL· GenBank· DDBJ
AAI39875.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp