The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity.
neprilysin x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes
Mrp1 triple knock-out mice lacking the genes for Mrp1 and Mdr1a/1b are more susceptible to developing features of chronic obstructive pulmonary disease (COPD) than their wild-type littermates.
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