A5CQP6 · COAD_CLAM3
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids163 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | substrate | |||
Binding site | 10-11 | ATP (UniProtKB | ChEBI) | |||
Binding site | 18 | ATP (UniProtKB | ChEBI) | |||
Site | 18 | Transition state stabilizer | |||
Binding site | 42 | substrate | |||
Binding site | 78 | substrate | |||
Binding site | 92 | substrate | |||
Binding site | 93-95 | ATP (UniProtKB | ChEBI) | |||
Binding site | 103 | ATP (UniProtKB | ChEBI) | |||
Binding site | 127-133 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Clavibacter
Accessions
- Primary accessionA5CQP6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000011124 | 1-163 | Phosphopantetheine adenylyltransferase | ||
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length163
- Mass (Da)17,472
- Last updated2007-06-12 v1
- MD5 Checksum9AC9D5936F35E00DB0C9CD2FEBF7077F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM711867 EMBL· GenBank· DDBJ | CAN01400.1 EMBL· GenBank· DDBJ | Genomic DNA |