A5CD09 · DUT_ORITB

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site67-69substrate
Binding site80substrate
Binding site84-86substrate
Binding site94substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • Ordered locus names
      OTBS_0580

Organism names

Accessions

  • Primary accession
    A5CD09

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000577771-148Deoxyuridine 5'-triphosphate nucleotidohydrolase

Structure

Family & Domains

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    148
  • Mass (Da)
    16,033
  • Last updated
    2007-06-12 v1
  • Checksum
    2D9205EB2098FB32
MKVKIKQIYQFEGASSLPAYSTNGSAGMDLYAAIASPMIIKPHETALVPAGIAISLPYGYEAQIRSRSGLASKFGVIVLNSPGTIDSDYRGELKIIMINLGQKDFQLTPAMRIAQMVIAKYEVVSWELVDDLDETERGKNGFGSSGLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM494475
EMBL· GenBank· DDBJ
CAM79646.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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