A5A6L1 · CCN1_PANTR
- ProteinCCN family member 1
- GeneCCN1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids381 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity).
CCN1-mediated gene regulation is dependent on heparin-binding (By similarity).
Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity).
Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
CCN1-mediated gene regulation is dependent on heparin-binding (By similarity).
Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity).
Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | growth factor binding | |
Molecular Function | heparin binding | |
Molecular Function | integrin binding | |
Biological Process | cell adhesion | |
Biological Process | chemotaxis | |
Biological Process | positive regulation of cell differentiation | |
Biological Process | positive regulation of cell migration | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCCN family member 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA5A6L1
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MSSRIARALALVVTLLHLTRLALS | ||||||
Chain | PRO_0000297553 | 25-381 | CCN family member 1 | |||
Sequence: TCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD | ||||||
Disulfide bond | 26↔50 | |||||
Sequence: CPAACHCPLEAPKCAPGVGLVRDGC | ||||||
Disulfide bond | 30↔52 | |||||
Sequence: CHCPLEAPKCAPGVGLVRDGCGC | ||||||
Disulfide bond | 32↔53 | |||||
Sequence: CPLEAPKCAPGVGLVRDGCGCC | ||||||
Disulfide bond | 39↔56 | |||||
Sequence: CAPGVGLVRDGCGCCKVC | ||||||
Disulfide bond | 64↔78 | |||||
Sequence: CSKTQPCDHTKGLEC | ||||||
Disulfide bond | 70↔91 | |||||
Sequence: CDHTKGLECNFGASSTALKGIC | ||||||
Modified residue | 188 | Phosphoserine | ||||
Sequence: S | ||||||
Disulfide bond | 286↔323 | |||||
Sequence: CSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCC | ||||||
Disulfide bond | 303↔337 | |||||
Sequence: CLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRC | ||||||
Disulfide bond | 314↔353 | |||||
Sequence: CGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSC | ||||||
Disulfide bond | 317↔355 | |||||
Sequence: CVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKC | ||||||
Disulfide bond | 322↔359 | |||||
Sequence: CCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-94 | IGFBP N-terminal | ||||
Sequence: TCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQ | ||||||
Domain | 98-164 | VWFC | ||||
Sequence: RPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEEWVCD | ||||||
Domain | 228-273 | TSP type-1 | ||||
Sequence: KCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCG | ||||||
Region | 279-315 | Heparin-binding | ||||
Sequence: SLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCG | ||||||
Domain | 286-360 | CTCK | ||||
Sequence: CSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP |
Sequence similarities
Belongs to the CCN family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length381
- Mass (Da)42,013
- Last updated2007-06-12 v1
- Checksum923330133F2A7F8B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB222139 EMBL· GenBank· DDBJ | BAF62384.1 EMBL· GenBank· DDBJ | mRNA |