A4ZZA8 · A4ZZA8_PAROL
- ProteinAlkaline phosphatase
- Genealp
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids476 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- a phosphate monoester + H2O = an alcohol + phosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion.
Note: Binds 2 Zn2+ ions.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 62 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 62 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 112 | Phosphoserine intermediate | ||||
Sequence: S | ||||||
Binding site | 173 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 175 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 332 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 337 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 341 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 378 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 379 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | alkaline phosphatase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlkaline phosphatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Carangaria > Pleuronectiformes > Pleuronectoidei > Paralichthyidae > Paralichthys
Accessions
- Primary accessionA4ZZA8
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Membrane ; Lipid-anchor, GPI-anchor
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MESAKGAILVLFLLVAFASSWA | ||||||
Chain | PRO_5007635186 | 23-476 | Alkaline phosphatase | |||
Sequence: KVEEENPEFWRSQARKTLQSALDRKLNTNVARNILLYLGDGMGITTYTAARILKGQLQNQTGEETVMTMDTFPSVGLAKTYSVDFQIPDSAATATAYLCGVKTNLNTIAVNAAARNGACRTQKGNEVTSILKWAKDAGKSVGIVTTTRVQHATPAASYAHSASRKWYSDANMPEAAKRDGCTDIASQLLNNTDIDVIIGGGRKYMTPRGTKDPEYPSDFSSRGKRKDGRNLINEWQSMKTGKVAHYVWNRTDFDAVDPDTTDYLMALFEPGDLRFEVERDPSMDPSIVETTEKAIRILQKNPNGFFLLVEGGRIDQAHHAGQAYMALHETVAFDYAIAKGLELTKEHETLTLVMADHSHPVTFNGYPFRGQSILGKSPLWATDMLPYTTLMYGNGPGHKLTNGTARNKLFTPPPPPVIHREHGSRFSGSAQCPPQFTAGTCTADVRSLFPCESH |
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)52,293
- Last updated2007-05-29 v1
- ChecksumC9816116007CD979