A4XQT0 · LPXC_PSEMY

Function

function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site78Zn2+ (UniProtKB | ChEBI)
Binding site237Zn2+ (UniProtKB | ChEBI)
Binding site241Zn2+ (UniProtKB | ChEBI)
Active site264Proton donor

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Molecular FunctionUDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-3-O-acyl-N-acetylglucosamine deacetylase
  • EC number
  • Short names
    UDP-3-O-acyl-GlcNAc deacetylase
  • Alternative names
    • UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase

Gene names

    • Name
      lpxC
    • Ordered locus names
      Pmen_0928

Organism names

Accessions

  • Primary accession
    A4XQT0

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000132201-303UDP-3-O-acyl-N-acetylglucosamine deacetylase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the LpxC family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    303
  • Mass (Da)
    33,594
  • Last updated
    2007-05-29 v1
  • Checksum
    3DB845227EA819DF
MIRQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFRRTDLDPIVEIRALAGNVGETTMSTTLVNGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAPKKFIRILREVTVVEGDKRATFVPFDGFKVSFEIDFDHPVFRNRTQSASVDFSSTSFVKEVSRARTFGFMRDIEFLRSQNLALGGSVENAIVVDEYRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFKGFKSGHALNNRLLRTLIEQTDAWEMVTFEDAKLAPISYMRPVAAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000680
EMBL· GenBank· DDBJ
ABP83696.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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