A4WUY6 · BETB_CERS5
- ProteinBetaine aldehyde dehydrogenase
- GenebetB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids483 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
Catalytic activity
- betaine aldehyde + H2O + NAD+ = glycine betaine + 2 H+ + NADHThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 potassium ions per subunit.
Pathway
Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 27 | K+ 1 (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 93 | K+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 149-151 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GAW | ||||||
Active site | 161 | Charge relay system | ||||
Sequence: K | ||||||
Binding site | 175-178 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: KPSE | ||||||
Binding site | 179 | K+ 1 (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 228-231 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: SVPT | ||||||
Binding site | 243 | K+ 2 (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Active site | 249 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 251 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Active site | 283 | Nucleophile | ||||
Sequence: C | ||||||
Binding site | 283 | NAD+ (UniProtKB | ChEBI); covalent | ||||
Sequence: C | ||||||
Binding site | 380 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 450 | K+ 2 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 453 | K+ 2 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Active site | 457 | Charge relay system | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | betaine-aldehyde dehydrogenase activity | |
Molecular Function | metal ion binding | |
Biological Process | glycine betaine biosynthetic process from choline |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBetaine aldehyde dehydrogenase
- EC number
- Short namesBADH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Cereibacter
Accessions
- Primary accessionA4WUY6
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000047056 | 1-483 | Betaine aldehyde dehydrogenase | |||
Sequence: MRAQPAASHFVDGRPLEDAAGAPIPVIHPANGEEIARLHEATPAVIEAALASGARAQKDWAALRPVERARILRRASDLIRARNEELSILETLDTGKPLQETLVADWPSGADALEFFAGLAPAVTGETVPLGQDFVYTIREPLGLCVGIGAWNYPSQIACWKAAPALALGNAMVFKPSEVTPLGALKLAEILIEAGLPPGLFNVVQGRGAVGAALVSDSRVAKVSLTGSVPTGRRVYAAAAEGVRHVTMELGGKSPLIVFDDADLESAIGAAMLGNFYSSGQICSNGTRVFVQKGIKEAFLARLAERADAIQMGDPLDPEVQMGPLVSPAQLEKVLSYIEKARAEGGRLVCGGEASVSPGCYVQPTVFADVTDGMTLAREEVFGPVMAVLDFETEEEVIARANATDFGLAAGVFTADLTRAHRVVAQLQAGTCWINAYNLTPVEAPFGGVKMSGVGRENGRAAVEHYTQVKSVYVGMGPVDAPY | ||||||
Modified residue | 283 | Cysteine sulfenic acid (-SOH) | ||||
Sequence: C |
Keywords
- PTM
Interaction
Structure
Sequence
- Sequence statusComplete
- Length483
- Mass (Da)50,779
- Last updated2007-05-29 v1
- Checksum03FB2EE7057CE106
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000661 EMBL· GenBank· DDBJ | ABP71200.1 EMBL· GenBank· DDBJ | Genomic DNA |