A4WUY6 · BETB_CERS5

Function

function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 2 potassium ions per subunit.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site27K+ 1 (UniProtKB | ChEBI)
Binding site93K+ 1 (UniProtKB | ChEBI)
Binding site149-151NAD+ (UniProtKB | ChEBI)
Active site161Charge relay system
Binding site175-178NAD+ (UniProtKB | ChEBI)
Binding site179K+ 1 (UniProtKB | ChEBI)
Binding site228-231NAD+ (UniProtKB | ChEBI)
Binding site243K+ 2 (UniProtKB | ChEBI)
Active site249Proton acceptor
Binding site251NAD+ (UniProtKB | ChEBI)
Active site283Nucleophile
Binding site283NAD+ (UniProtKB | ChEBI); covalent
Binding site380NAD+ (UniProtKB | ChEBI)
Binding site450K+ 2 (UniProtKB | ChEBI)
Binding site453K+ 2 (UniProtKB | ChEBI)
Active site457Charge relay system

GO annotations

AspectTerm
Molecular Functionbetaine-aldehyde dehydrogenase activity
Molecular Functionmetal ion binding
Biological Processglycine betaine biosynthetic process from choline

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Betaine aldehyde dehydrogenase
  • EC number
  • Short names
    BADH

Gene names

    • Name
      betB
    • Ordered locus names
      Rsph17025_2311

Organism names

Accessions

  • Primary accession
    A4WUY6

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_10000470561-483Betaine aldehyde dehydrogenase
Modified residue283Cysteine sulfenic acid (-SOH)

Keywords

Interaction

Subunit

Dimer of dimers.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    483
  • Mass (Da)
    50,779
  • Last updated
    2007-05-29 v1
  • Checksum
    03FB2EE7057CE106
MRAQPAASHFVDGRPLEDAAGAPIPVIHPANGEEIARLHEATPAVIEAALASGARAQKDWAALRPVERARILRRASDLIRARNEELSILETLDTGKPLQETLVADWPSGADALEFFAGLAPAVTGETVPLGQDFVYTIREPLGLCVGIGAWNYPSQIACWKAAPALALGNAMVFKPSEVTPLGALKLAEILIEAGLPPGLFNVVQGRGAVGAALVSDSRVAKVSLTGSVPTGRRVYAAAAEGVRHVTMELGGKSPLIVFDDADLESAIGAAMLGNFYSSGQICSNGTRVFVQKGIKEAFLARLAERADAIQMGDPLDPEVQMGPLVSPAQLEKVLSYIEKARAEGGRLVCGGEASVSPGCYVQPTVFADVTDGMTLAREEVFGPVMAVLDFETEEEVIARANATDFGLAAGVFTADLTRAHRVVAQLQAGTCWINAYNLTPVEAPFGGVKMSGVGRENGRAAVEHYTQVKSVYVGMGPVDAPY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000661
EMBL· GenBank· DDBJ
ABP71200.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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