A4W070 · AROK_STRS2
- ProteinShikimate kinase
- GenearoK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids163 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Catalytic activity
- ATP + shikimate = 3-phosphoshikimate + ADP + H+
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10-15 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GVGKTT | ||||||
Binding site | 14 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 28 | substrate | ||||
Sequence: D | ||||||
Binding site | 52 | substrate | ||||
Sequence: R | ||||||
Binding site | 75 | substrate | ||||
Sequence: G | ||||||
Binding site | 116 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 134 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | shikimate kinase activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate kinase
- EC number
- Short namesSK
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionA4W070
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000094425 | 1-163 | Shikimate kinase | |||
Sequence: MPIVLLGFMGVGKTTTAHLLNLPVYDMDHIIEERIGMPIADYFSLEGEASFRQLETEVLKGLLDLPSNCIVSTGGGVIKSEVNRELLLANREDNVLLTASFEVSYQRIRKDRQSQRPLFLQCSKEEFEALYRERMALYQGLADTVIDTDKLIPEQVARKILCK |
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length163
- Mass (Da)18,463
- Last updated2007-05-29 v1
- Checksum240DE2FE9D92B34A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000408 EMBL· GenBank· DDBJ | ABP91759.1 EMBL· GenBank· DDBJ | Genomic DNA |