A4UQV6 · A4UQV6_DANRE
- ProteinNcx4a
- Geneslc8a4a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids939 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- Ca2+(in) + 3 Na+(out) = Ca2+(out) + 3 Na+(in)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | postsynapse | |
Cellular Component | sarcolemma | |
Molecular Function | calcium:sodium antiporter activity | |
Molecular Function | calmodulin binding | |
Molecular Function | metal ion binding | |
Biological Process | calcium ion import across plasma membrane | |
Biological Process | cell communication | |
Biological Process | determination of left/right symmetry | |
Biological Process | fluid transport | |
Biological Process | heart contraction | |
Biological Process | heart looping | |
Biological Process | regulation of cytosolic calcium ion concentration | |
Biological Process | skeletal muscle tissue development | |
Biological Process | sodium ion transmembrane transport |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA4UQV6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 77-95 | Helical | ||||
Sequence: AIVYFVALIYMFLGMSIIA | ||||||
Transmembrane | 136-153 | Helical | ||||
Sequence: LTLMALGSSAPEILLSVI | ||||||
Transmembrane | 165-190 | Helical | ||||
Sequence: LGPSTIVGSAAFNMFIIIALCVYVVP | ||||||
Transmembrane | 202-225 | Helical | ||||
Sequence: VFFVTAAWSIFAYIWLYLILSVFS | ||||||
Transmembrane | 231-250 | Helical | ||||
Sequence: VWEAVLTFLFFPLCVVQAWI | ||||||
Transmembrane | 763-782 | Helical | ||||
Sequence: WNGWACFIVSITLIGVLTAV | ||||||
Transmembrane | 840-860 | Helical | ||||
Sequence: AVNVFLGIGVAWTIAAVYWHS | ||||||
Transmembrane | 872-891 | Helical | ||||
Sequence: LAFSVTLFTILALVCVVTLL | ||||||
Transmembrane | 911-930 | Helical | ||||
Sequence: LLTAFLFIVLWLIYIMLASL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-36 | |||||
Sequence: MFHLRLSRSSFSSITPCLSSVLLLIFLSGLTHLSQA | ||||||
Chain | PRO_5035034769 | 37-939 | ||||
Sequence: SGDVSHSGPGNCSGEDSCSEGVVLPIWNPQNPSVGDKVARAIVYFVALIYMFLGMSIIADRFMSSIEVITSQEKEITIKKPNGETTTATVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHKFEAGHLGPSTIVGSAAFNMFIIIALCVYVVPDGEVRKIKHLRVFFVTAAWSIFAYIWLYLILSVFSPGVVEVWEAVLTFLFFPLCVVQAWIADRRLLFYKYVHKRYRTDKNRGIIIETEGDGMFTKMDMEMDGQGANSHHKEALDGMLAGVEEGGGGGEEEEARREMARTLKELKQRHPEKDMEQLIEMANYQVLVQQQKSRAFYRIQATRMMIGAGNILKKHAADQARKVVSCHEANPQEEDPHTIYLEFEPSHYQCFENCGSLKLSVTRHGGDSGCTVKVDYRTEDGTANAGSDYEFAEGTLVFKPGETVKELTVGVIDDDIFEEDEHFYVHLSNPRVVHRAEVSILDPNAVSPGNSIIGSSHVPPKAALGNAHSATVTIYDDDHAGIFTFESNSTRVSESVGIMQVKVHRTSGARGKVAVPYHTTEGTAKAGEDYDEVAGKLEFLNDETMKILEVKIIDDEEYEKNKTFTIHLGEPVLLEIGQKHGDSNDNKPAVGAEEEEVAKMGCPSLGEHTKLEVVIEESYEFKNTVDKLIKKTNLALVVGSSSWREQFVSAVTVSAGDDDEEESGEERLPSCFDYIMHFLTVFWKVLFAFVPPTEYWNGWACFIVSITLIGVLTAVTGDLASHFGCTVGLKDTVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVTGSNAVNVFLGIGVAWTIAAVYWHSQGKKFQVPPGSLAFSVTLFTILALVCVVTLLYRRRPSVSGGELGGPRTPKLLTAFLFIVLWLIYIMLASLEAYCHVPGF |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 395-495 | Calx-beta | ||||
Sequence: EANPQEEDPHTIYLEFEPSHYQCFENCGSLKLSVTRHGGDSGCTVKVDYRTEDGTANAGSDYEFAEGTLVFKPGETVKELTVGVIDDDIFEEDEHFYVHLS | ||||||
Domain | 537-636 | Calx-beta | ||||
Sequence: ATVTIYDDDHAGIFTFESNSTRVSESVGIMQVKVHRTSGARGKVAVPYHTTEGTAKAGEDYDEVAGKLEFLNDETMKILEVKIIDDEEYEKNKTFTIHLG |
Sequence similarities
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length939
- Mass (Da)103,202
- Last updated2007-05-15 v1
- ChecksumA1C7A8A1C39E9025
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX324159 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
EF470289 EMBL· GenBank· DDBJ | ABO93326.1 EMBL· GenBank· DDBJ | mRNA | ||
EU559290 EMBL· GenBank· DDBJ | ACB45519.1 EMBL· GenBank· DDBJ | mRNA |