A4UCT1 · A4UCT1_HUMAN

  • Protein
    glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

GO annotations

AspectTerm
Cellular Componentcytoskeleton
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionNAD binding
Molecular Functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Molecular Functiontransferase activity
Biological Processapoptotic process
Biological Processglycolytic process
Biological Processregulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
  • EC number
  • Alternative names
    • Peptidyl-cysteine S-nitrosylase GAPDH

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A4UCT1

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

Interaction

Subunit

Homotetramer. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules. Interacts with EIF1AD, USP25, PRKCI and WARS1. Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity. Interacts with TRAF2, promoting TRAF2 ubiquitination. Interacts with TRAF3, promoting TRAF3 ubiquitination.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-64Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    166
  • Mass (Da)
    17,303
  • Last updated
    2007-05-15 v1
  • MD5 Checksum
    D0116E715B893E6E587489D1B327C141
DAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue166

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF036498
EMBL· GenBank· DDBJ
ABO65084.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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