A4T163 · FGD_MYCGI
- ProteinF420-dependent glucose-6-phosphate dehydrogenase
- Genefgd
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids336 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.
Catalytic activity
- D-glucose 6-phosphate + H+ + oxidized coenzyme F420-(gamma-L-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)
CHEBI:61548 + CHEBI:15378 + oxidized coenzyme F420-(γ-L-Glu)(n) RHEA-COMP:12939 = CHEBI:57955 + reduced coenzyme F420-(γ-L-Glu)(n) RHEA-COMP:14378
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 39 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 40 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 76 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 107-108 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: TG | ||||||
Active site | 109 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 112 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 177-178 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: GG | ||||||
Binding site | 180-181 | coenzyme F420-(gamma-Glu)n (UniProtKB | ChEBI) | ||||
Sequence: QV | ||||||
Binding site | 195 | substrate | ||||
Sequence: T | ||||||
Binding site | 198 | substrate | ||||
Sequence: K | ||||||
Binding site | 259 | substrate | ||||
Sequence: K | ||||||
Binding site | 283 | substrate | ||||
Sequence: R |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Molecular Function | coenzyme F420 binding | |
Molecular Function | glucose-6-phosphate dehydrogenase (coenzyme F420) activity | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
Biological Process | carbohydrate metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameF420-dependent glucose-6-phosphate dehydrogenase
- EC number
- Short namesFGD ; G6PD
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA4T163
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000413594 | 1-336 | F420-dependent glucose-6-phosphate dehydrogenase | |||
Sequence: MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGGHAPFSLAWMTAVGERTTRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPDRIFLGVGTGEALNEIATGYEGEWPEFKERYARLRESVRLMRELWLGDRVDFEGEYYKTKGASIYDVPEGGIPIYIAAGGPQVAKYAGRAGDGFICTSGKGEELYKEKLIPAMREGAEAAGKNPDDVDRMIEIKISYDTDPELALENTRFWAPLSLTAEQKHSIDDPMEMEKAADELPIEQVAKRWIVASDPDEAVAKVADYVDYGLNHLVFHAPGHDQRRFLELFQRDLEPRLRKLG |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length336
- Mass (Da)37,560
- Last updated2007-05-15 v1
- ChecksumA119BE48529ED73E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000656 EMBL· GenBank· DDBJ | ABP42706.1 EMBL· GenBank· DDBJ | Genomic DNA |