A4QXX4 · SSN3_PYRO7

Function

function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site67-75ATP (UniProtKB | ChEBI)
Binding site91ATP (UniProtKB | ChEBI)
Active site193Proton acceptor

GO annotations

AspectTerm
Cellular ComponentCKM complex
Cellular Componentmediator complex
Molecular FunctionATP binding
Molecular Functioncyclin-dependent protein serine/threonine kinase activity
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Molecular FunctionRNA polymerase II CTD heptapeptide repeat kinase activity
Biological Processnegative regulation of filamentous growth
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnuclear-transcribed mRNA catabolic process, non-stop decay
Biological Processpositive regulation of developmental process
Biological Processpositive regulation of transcription from RNA polymerase II promoter by galactose
Biological Processprotein destabilization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      SSN3
    • Synonyms
      CDK8
    • ORF names
      MGG_13931

Organism names

Accessions

  • Primary accession
    A4QXX4
  • Secondary accessions
    • G4N9S7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003129471-499Serine/threonine-protein kinase SSN3

Interaction

Subunit

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues
Region1-21Disordered
Domain61-442Protein kinase
Region332-376Disordered
Compositional bias358-376Polar residues
Region463-499Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    499
  • Mass (Da)
    55,094
  • Last updated
    2008-01-15 v2
  • Checksum
    4D6D22BA3A00FAA1
MSHSNPPTGASGGPGSASASAAPARGYYSLKRSIQTAFNDPLDRGLGPPAYQSKVRVMDKYQVIGFISSGTYGRVYKARGRQGQPGEFAIKKFKPDKEGEQITYTGISQSAIREMALCSELRHPNVIRLVETILEDKAIFMVFEYAEHDLLQIIHHHTQQPKHPIPPQTIKSIMFQLLNGCQYLHTNWVLHRDLKPANIMVTSSGEVKVGDLGLARIFWKPVRTLMQGDKVVVTIWYRAPELLMGSHHYTPAVDMWAVGCIFAELLSLRPIFKGEEAKMDNTKKGGSRDMPFQRHQMQKIVDIMGMPTKERWPLLTSMPDYDKLPLLQPPLSASGYSQQPAHSHHHHQHYNQGPQYGGRAGGPTSSSSANSSSAAAAASQSHLDKWYYHTVSQGQTAGPMPHAPPGSLASLGVEGYKLLAGLLEYDPEKRLTAAAALQHNFFSTGDRVSANCFEGCKAEYPHRRVSQEDNDIRTGSVPGTKRSGMPDDSMGRPGKRVKE

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
G4N9S8G4N9S8_PYRO7MGG_13931468

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues
Compositional bias358-376Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM001234
EMBL· GenBank· DDBJ
EHA49585.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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