Fibronectin was identified as a target of mMCP-5 and the exocytosis of mMCP-5 from the MCs in the mouse's peritoneal cavity resulted in the expression of metalloproteinase protease-9 which has been implicated in arthritis.
Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA whereas mast cells that do not express chymase mainly produce FXIIIA
Results suggest that mouse mast cell proteases 4 5 and 6 are mediators of the critical role mast cells play in microdeformational wound therapy in the proliferative phase of healing.
Data indicate that a second-degree burn injury can initiate an immediate novel zonal degranulation of mast cell throughout all skin layers and a disruption of the epidermal tight junctions dependent on the nonredundant presence of mMCP4 and mMCP5.
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