A4QN18 · A4QN18_HUMAN
- ProteinProtein transport protein sec16
- GeneSEC16A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1961 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum exit site | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Biological Process | autophagy | |
Biological Process | COPII vesicle coating | |
Biological Process | protein transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein transport protein sec16
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA4QN18
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Interaction
Subunit
SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-47 | Disordered | ||||
Sequence: MFFQGGETENEENLSSEKAGLSGQADFDDFCSSPGLGRPPAPTHVGA | ||||||
Region | 137-167 | Disordered | ||||
Sequence: DATLHTVHPDSVSSSYSSRSHGRLSGSARPQ | ||||||
Compositional bias | 143-161 | Polar residues | ||||
Sequence: VHPDSVSSSYSSRSHGRLS | ||||||
Region | 180-230 | Disordered | ||||
Sequence: KPEDEASGSFFKQIDSSPVGGETDETTVSQNYRGSVSQPSTPSPPKPTGIF | ||||||
Compositional bias | 189-218 | Polar residues | ||||
Sequence: FFKQIDSSPVGGETDETTVSQNYRGSVSQP | ||||||
Region | 385-455 | Disordered | ||||
Sequence: VQPPEEAMSGQQSRNPSSAAPVQSRGGIGASENLENPPKMGEEEALQSQASSGYASLLSSPPTESLQNPPV | ||||||
Compositional bias | 390-408 | Polar residues | ||||
Sequence: EAMSGQQSRNPSSAAPVQS | ||||||
Compositional bias | 429-455 | Polar residues | ||||
Sequence: ALQSQASSGYASLLSSPPTESLQNPPV | ||||||
Region | 551-614 | Disordered | ||||
Sequence: LLVQPPSQPVPENLVPESQKDRKAGSALPGFANSPAGSTSVVLVPPAHGTLVPDGNKANHSSHQ | ||||||
Compositional bias | 633-656 | Polar residues | ||||
Sequence: VNVYNPSHSDSLASQQSVASHPRQ | ||||||
Region | 633-665 | Disordered | ||||
Sequence: VNVYNPSHSDSLASQQSVASHPRQSGPGAPNLD | ||||||
Region | 686-778 | Disordered | ||||
Sequence: QELVPPQQQASPPQLPKAMFSELSNPESLPAQGQAQNSAQSPASLVLVDAGQQLPPRPPQSSSVSLVSSGSGQAAVPSEQPWPQPVPALAPGP | ||||||
Compositional bias | 710-732 | Polar residues | ||||
Sequence: NPESLPAQGQAQNSAQSPASLVL | ||||||
Compositional bias | 740-763 | Polar residues | ||||
Sequence: PPRPPQSSSVSLVSSGSGQAAVPS | ||||||
Region | 842-875 | Disordered | ||||
Sequence: YPEPERPSSRASHSSERPPPRQGYPEGYYSSKSG | ||||||
Compositional bias | 934-983 | Basic and acidic residues | ||||
Sequence: FGDRPEKRDNNWRYDPRFTGSFDDDPDPHRDPYGEEVDRRSVHSEHSARS | ||||||
Region | 934-1005 | Disordered | ||||
Sequence: FGDRPEKRDNNWRYDPRFTGSFDDDPDPHRDPYGEEVDRRSVHSEHSARSLHSAHSLASRRSSLSSHSHQSQ | ||||||
Compositional bias | 984-1005 | Polar residues | ||||
Sequence: LHSAHSLASRRSSLSSHSHQSQ | ||||||
Domain | 1077-1176 | Sec16 central conserved | ||||
Sequence: VCARFGPGGQLIKVIPNLPSEGQPALVEVHSMEALLQHTSEQEEMRAFPGPLAKDDTHKVDVINFAQNKAMKCLQNENLIDKESASLLWNFIVLLCRQNG | ||||||
Domain | 1249-1483 | Ancestral coatomer element 1 Sec16/Sec31 | ||||
Sequence: RELLLYGRKKDALESAMKNGLWGHALLLASKMDSRTHARVMTRFANSLPINDPLQTVYQLMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTMATMGDTLASRGLLDAAHFCYLMAQAGFGVYTKKTTKLVLIGSNHSLPFLKFATNEAIQRTEAYEYAQSLGAETCPLPSFQVFKFIYSCRLAEMGLATQAFHYCEAIAKSILTQPHLYSPVLISQLVQMASQLR | ||||||
Region | 1676-1737 | Disordered | ||||
Sequence: KFANLTPSRTVPDSEAPPGWDRADSGPTQPPLSLSPAPETKRPGQAAKKETKEPKKGESWFF | ||||||
Compositional bias | 1718-1737 | Basic and acidic residues | ||||
Sequence: PGQAAKKETKEPKKGESWFF | ||||||
Region | 1770-1808 | Disordered | ||||
Sequence: LNEPEEEKKAPPPPPTSMPKTVQAAPPAFPGPPGAPVNM | ||||||
Compositional bias | 1780-1803 | Pro residues | ||||
Sequence: PPPPPTSMPKTVQAAPPAFPGPPG | ||||||
Region | 1847-1932 | Disordered | ||||
Sequence: PLPIPSNLFVPTPVSSVRPQGRSGRNDGLLALSSPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKAPGDLPAAGGPPSGAMPFY |
Sequence similarities
Belongs to the SEC16 family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,961
- Mass (Da)211,075
- Last updated2007-05-15 v1
- Checksum41BC6A5184409E53
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 143-161 | Polar residues | ||||
Sequence: VHPDSVSSSYSSRSHGRLS | ||||||
Compositional bias | 189-218 | Polar residues | ||||
Sequence: FFKQIDSSPVGGETDETTVSQNYRGSVSQP | ||||||
Compositional bias | 390-408 | Polar residues | ||||
Sequence: EAMSGQQSRNPSSAAPVQS | ||||||
Compositional bias | 429-455 | Polar residues | ||||
Sequence: ALQSQASSGYASLLSSPPTESLQNPPV | ||||||
Compositional bias | 633-656 | Polar residues | ||||
Sequence: VNVYNPSHSDSLASQQSVASHPRQ | ||||||
Compositional bias | 710-732 | Polar residues | ||||
Sequence: NPESLPAQGQAQNSAQSPASLVL | ||||||
Compositional bias | 740-763 | Polar residues | ||||
Sequence: PPRPPQSSSVSLVSSGSGQAAVPS | ||||||
Compositional bias | 934-983 | Basic and acidic residues | ||||
Sequence: FGDRPEKRDNNWRYDPRFTGSFDDDPDPHRDPYGEEVDRRSVHSEHSARS | ||||||
Compositional bias | 984-1005 | Polar residues | ||||
Sequence: LHSAHSLASRRSSLSSHSHQSQ | ||||||
Compositional bias | 1718-1737 | Basic and acidic residues | ||||
Sequence: PGQAAKKETKEPKKGESWFF | ||||||
Compositional bias | 1780-1803 | Pro residues | ||||
Sequence: PPPPPTSMPKTVQAAPPAFPGPPG |