A4K2M4 · KCNS1_PAPAN
- ProteinPotassium voltage-gated channel subfamily S member 1
- GeneKCNS1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids529 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | voltage-gated potassium channel complex | |
Molecular Function | delayed rectifier potassium channel activity | |
Molecular Function | potassium channel regulator activity | |
Biological Process | potassium ion transport | |
Biological Process | protein homooligomerization | |
Biological Process | regulation of delayed rectifier potassium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePotassium voltage-gated channel subfamily S member 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Papio
Accessions
- Primary accessionA4K2M4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-217 | Cytoplasmic | ||||
Sequence: MLMLLVRGTHYESLRSKVVLPTPLGGRSTEALVSECPIPDTGIRWRQSDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSL | ||||||
Transmembrane | 218-239 | Helical; Name=Segment S1 | ||||
Sequence: PSKLFSCVSISVVLASIAAMCI | ||||||
Topological domain | 240-270 | Extracellular | ||||
Sequence: HSLPEYQAREAAAAVAAVAAGRSPEGVRDDP | ||||||
Transmembrane | 271-293 | Helical; Name=Segment S2 | ||||
Sequence: VLRRLEYFCIAWFSFEVSSRLLL | ||||||
Topological domain | 294-304 | Cytoplasmic | ||||
Sequence: APSTRNFFCHP | ||||||
Transmembrane | 305-322 | Helical; Name=Segment S3 | ||||
Sequence: LNLIDIVSVLPFYLTLLA | ||||||
Topological domain | 323-340 | Extracellular | ||||
Sequence: GVALGDQGGTGGKELGHL | ||||||
Transmembrane | 341-361 | Helical; Voltage-sensor; Name=Segment S4 | ||||
Sequence: GKVVQVFRLMRIFRVLKLARH | ||||||
Topological domain | 362-376 | Cytoplasmic | ||||
Sequence: STGLRSLGATLKHSY | ||||||
Transmembrane | 377-398 | Helical; Name=Segment S5 | ||||
Sequence: REVGILLLYLAVGVSVFSGVAY | ||||||
Topological domain | 399-411 | Extracellular | ||||
Sequence: TAEKEEDVGFNTI | ||||||
Intramembrane | 412-423 | Helical; Name=Pore helix | ||||
Sequence: PACWWWGTVSMT | ||||||
Intramembrane | 424-431 | |||||
Sequence: TVGYGDVV | ||||||
Topological domain | 432-438 | Extracellular | ||||
Sequence: PVTVAGK | ||||||
Transmembrane | 439-467 | Helical; Name=Segment S6 | ||||
Sequence: LAASGCILGGILVVALPITIIFNKFSHFY | ||||||
Topological domain | 468-529 | Cytoplasmic | ||||
Sequence: RRQKALEAAVRNSNHQEFEDLLSSVDAVSEASLETSRETSQEGRSADLETQAPSEPPHPQMY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000289621 | 1-529 | Potassium voltage-gated channel subfamily S member 1 | |||
Sequence: MLMLLVRGTHYESLRSKVVLPTPLGGRSTEALVSECPIPDTGIRWRQSDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSVDAVSEASLETSRETSQEGRSADLETQAPSEPPHPQMY |
Expression
Gene expression databases
Interaction
Subunit
Heteromultimer with KCNB1 and KCNB2. Does not form homomultimers.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 424-429 | Selectivity filter | ||||
Sequence: TVGYGD | ||||||
Region | 496-529 | Disordered | ||||
Sequence: SEASLETSRETSQEGRSADLETQAPSEPPHPQMY |
Domain
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length529
- Mass (Da)58,385
- Last updated2007-05-01 v1
- ChecksumD5A57F2CE39675CC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DP000036 EMBL· GenBank· DDBJ | ABO52907.1 EMBL· GenBank· DDBJ | Genomic DNA |