A4K2M4 · KCNS1_PAPAN

  • Protein
    Potassium voltage-gated channel subfamily S member 1
  • Gene
    KCNS1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componentvoltage-gated potassium channel complex
Molecular Functiondelayed rectifier potassium channel activity
Molecular Functionpotassium channel regulator activity
Biological Processpotassium ion transport
Biological Processprotein homooligomerization
Biological Processregulation of delayed rectifier potassium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Potassium voltage-gated channel subfamily S member 1
  • Alternative names
    • Delayed-rectifier K(+) channel alpha subunit 1

Gene names

    • Name
      KCNS1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Papio

Accessions

  • Primary accession
    A4K2M4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-217Cytoplasmic
Transmembrane218-239Helical; Name=Segment S1
Topological domain240-270Extracellular
Transmembrane271-293Helical; Name=Segment S2
Topological domain294-304Cytoplasmic
Transmembrane305-322Helical; Name=Segment S3
Topological domain323-340Extracellular
Transmembrane341-361Helical; Voltage-sensor; Name=Segment S4
Topological domain362-376Cytoplasmic
Transmembrane377-398Helical; Name=Segment S5
Topological domain399-411Extracellular
Intramembrane412-423Helical; Name=Pore helix
Intramembrane424-431
Topological domain432-438Extracellular
Transmembrane439-467Helical; Name=Segment S6
Topological domain468-529Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002896211-529Potassium voltage-gated channel subfamily S member 1

Expression

Gene expression databases

Interaction

Subunit

Heteromultimer with KCNB1 and KCNB2. Does not form homomultimers.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif, region.

TypeIDPosition(s)Description
Motif424-429Selectivity filter
Region496-529Disordered

Domain

The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    529
  • Mass (Da)
    58,385
  • Last updated
    2007-05-01 v1
  • Checksum
    D5A57F2CE39675CC
MLMLLVRGTHYESLRSKVVLPTPLGGRSTEALVSECPIPDTGIRWRQSDEALRVNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAHEFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPRAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGTGGKELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSVDAVSEASLETSRETSQEGRSADLETQAPSEPPHPQMY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DP000036
EMBL· GenBank· DDBJ
ABO52907.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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