A4K144 · M2_I54A2
- ProteinMatrix protein 2
- GeneM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Miscellaneous
Activity regulation
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 37 | Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter | ||||
Sequence: H | ||||||
Site | 41 | Seems to be involved in pH gating | ||||
Sequence: W |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell plasma membrane | |
Cellular Component | membrane | |
Cellular Component | virion membrane | |
Molecular Function | monoatomic ion channel activity | |
Molecular Function | proton transmembrane transporter activity | |
Biological Process | protein complex oligomerization | |
Biological Process | suppression by virus of host autophagy | |
Biological Process | symbiont genome entry into host cell via pore formation in plasma membrane |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMatrix protein 2
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus
- Virus hosts
Accessions
- Primary accessionA4K144
Proteomes
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-22 | Virion surface | ||||
Sequence: MSLLTEVETPIRNEWGCRCNDS | ||||||
Transmembrane | 23-43 | Helical; Signal-anchor for type III membrane protein | ||||
Sequence: SDPLIIAASVVGILHLILWIL | ||||||
Topological domain | 44-97 | Intravirion | ||||
Sequence: DRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVNIELE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation, lipidation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000372924 | 1-97 | Matrix protein 2 | |||
Sequence: MSLLTEVETPIRNEWGCRCNDSSDPLIIAASVVGILHLILWILDRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVNIELE | ||||||
Disulfide bond | 17 | Interchain (with C-17) | ||||
Sequence: C | ||||||
Disulfide bond | 19 | Interchain (with C-19) | ||||
Sequence: C | ||||||
Glycosylation | 20 | N-linked (GlcNAc...) asparagine; by host | ||||
Sequence: N | ||||||
Lipidation | 50 | S-palmitoyl cysteine; by host | ||||
Sequence: C | ||||||
Modified residue | 64 | Phosphoserine; by host | ||||
Sequence: S | ||||||
Modified residue | 82 | Phosphoserine; by host | ||||
Sequence: S |
Keywords
- PTM
PTM databases
Interaction
Subunit
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 59-85 | Disordered | ||||
Sequence: LKRGPSTEGVPESMREEYRKEQQSAVD | ||||||
Compositional bias | 67-85 | Basic and acidic residues | ||||
Sequence: GVPESMREEYRKEQQSAVD |
Domain
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Only the first 9 residues are shared by the 2 isoforms.
A4K144-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameM2
- Length97
- Mass (Da)11,178
- Last updated2007-05-01 v1
- ChecksumF5E32A76722994B6
A4K145-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- NameM1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 67-85 | Basic and acidic residues | ||||
Sequence: GVPESMREEYRKEQQSAVD |
Keywords
- Coding sequence diversity
- Technical term