A4JBR4 · NADK_BURVG
- ProteinNAD kinase
- GenenadK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids300 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity
- ATP + NAD+ = ADP + H+ + NADP+
Cofactor
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 75 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 75-76 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: DG | ||||||
Binding site | 149-150 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: ND | ||||||
Binding site | 177 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 179 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 190-195 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TAYALS | ||||||
Binding site | 214 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 248 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD binding | |
Molecular Function | NAD+ kinase activity | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex
Accessions
- Primary accessionA4JBR4
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000005396 | 1-300 | NAD kinase | |||
Sequence: MKTGNQFNTVALVGRSNTPGIAEPLATLAGCIAKLGFDVVFEADTAREIGISGYPALTPAEIGARADVAVVLGGDGTMLGIGRQLAPYKTPLIGINHGRLGFITDIAAADMQALVPVILSGKFEREERSLLEARIVRNGEPIYHALAFNDVVVNRSGFSGMVELRASVDGRYMYNQRSDGLIVATPTGSTAYALSSAGPILHPQLQGVVLVPIAPHALSNRPIVLPDDSKIAIQIVAGRDVNVNFDMQSFTALELNDTIEVRRSKHTVPFLHPIGYSYYATLRKKLHWNEHASNEDDKAS |
Structure
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)32,227
- Last updated2007-05-01 v1
- Checksum88165CB111F53B25
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000614 EMBL· GenBank· DDBJ | ABO53717.1 EMBL· GenBank· DDBJ | Genomic DNA |