A4IHB9 · SL9B2_XENTR

Function

function

Electroneutral Na+ Li+/H+ antiporter that extrudes Na+ or Li+ in exchange for external protons across the membrane (By similarity).
Uses the proton gradient/membrane potential to extrude sodium (By similarity).
Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity).
Also able to mediate Na+/Li+ antiporter activity in kidney (By similarity).

Miscellaneous

The subcellular localization of SLC9B2 remains controversial. Was initially thought to partially localize to mitochondria. However SLC9B2 does not seem to contain a mitochondrial targeting sequence. It was later established that its localizes predominantly in plasma membrane or intracellularly to endosomes and lysosomes (By similarity).
In another recent study, endogenous SLC9B2 in the distal tubular cell line mpkDCT4 is detected in recycling endosomes but absent in plasma membrane (By similarity).

Catalytic activity

Activity regulation

Allosterically inhibited by the N-terminal domain. Inhibited by phloretin.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site252Na+ (UniProtKB | ChEBI)
Binding site283Na+ (UniProtKB | ChEBI)
Binding site286Na+ (UniProtKB | ChEBI)
Binding site287Na+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentmitochondrial membrane
Cellular Componentrecycling endosome
Cellular Componentrecycling endosome membrane
Cellular Componentsynaptic vesicle membrane
Molecular Functionantiporter activity
Molecular Functionmetal ion binding
Biological Processproton transmembrane transport
Biological Processsodium ion homeostasis
Biological Processsodium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/hydrogen exchanger 9B2
  • Alternative names
    • Na(+)/H(+) exchanger NHA2
    • Na(+)/H(+) exchanger-like domain-containing protein 2 (NHE domain-containing protein 2)
    • Sodium/hydrogen exchanger-like domain-containing protein 2
    • Solute carrier family 9 subfamily B member 2

Gene names

    • Name
      slc9b2
    • Synonyms
      nha2, nhedc2

Organism names

Accessions

  • Primary accession
    A4IHB9

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
; Multi-pass membrane protein
Basolateral cell membrane
; Multi-pass membrane protein
Apical cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-94Cytoplasmic
Transmembrane95-112Helical; Name=1
Topological domain113-121Extracellular
Transmembrane122-141Helical; Name=2
Topological domain142-152Cytoplasmic
Transmembrane153-169Helical; Name=3
Topological domain170-179Extracellular
Transmembrane180-197Helical; Name=4
Topological domain198-208Cytoplasmic
Transmembrane209-235Helical; Name=5
Topological domain236-241Extracellular
Transmembrane242-250Helical; Name=6
Topological domain251-278Cytoplasmic
Transmembrane279-298Helical; Name=7
Topological domain299-308Extracellular
Transmembrane309-332Helical; Name=8
Topological domain333-347Cytoplasmic
Transmembrane348-365Helical; Name=9
Topological domain366-369Extracellular
Transmembrane370-381Helical; Name=10
Topological domain382-398Cytoplasmic
Transmembrane399-419Helical; Name=11
Topological domain420-425Extracellular
Transmembrane426-448Helical; Name=12
Topological domain449-469Cytoplasmic
Transmembrane470-481Helical; Name=13
Topological domain482-494Extracellular
Transmembrane495-517Helical; Name=14
Topological domain518-539Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003312731-539Sodium/hydrogen exchanger 9B2

Proteomic databases

Interaction

Subunit

Homodimer; dimerization is essential for SLC9B2 activity. Lipids seem to play a role in the stabilization of the dimerization subdomain.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    539
  • Mass (Da)
    57,148
  • Last updated
    2007-05-01 v1
  • Checksum
    53E7582EA2CA634C
MEDSLFSVDKAGPGKDASAASADCNHMVAEDGIITEQHKEIPLVALKVPDGHAPIDECELLNSDDQLPKGSQNQTNICMRIRAFACPPQGCFSLAITNVTMVILIWAVVWSITGPECLPGGNLFGILALLFSAALGGKLISLIKIPSLPPLPPLLGMLLAGFLIRNIPVITDQVQIHHKWSAALRNIALAIILVRAGLGLDPKALRKLKAVCLRLSFGPCVVESCTAAVVSHFIMGFPLTWGFMLGFVLGAVSPAVVVPSMLILQKEGFGVDKGIPTLLMAAGSFDDVLAITGFNTCLGMAFSSGSTLNTIVRGVLEVVVGIAAGLLFGFFLHYFPSKDQENLKGKRSYLILALSVFAVFGSLYFGFPGSGGLCTLVMAFLAGIGWSTDKTVVEDIIAVSWDIFQPLLFGLIGAEISVASLKPETVGLCTATLIIALIIRICISFLMVCFSGFSLKEKIFISLAWMPKATVQAAIGSVALDTARTLENKQFEDYGMDVLTVAFLGILVTAPIGALVIGLTGPKMLEKSESRTVTEEGSV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC135456
EMBL· GenBank· DDBJ
AAI35457.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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