A4HXK2 · A4HXK2_LEIIN

  • Protein
    RNA cytidine acetyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N4-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site294-303ATP (UniProtKB | ChEBI)
Binding site462ATP (UniProtKB | ChEBI)
Binding site635-637acetyl-CoA (UniProtKB | ChEBI)
Binding site642-648acetyl-CoA (UniProtKB | ChEBI)
Binding site747acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Component90S preribosome
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctionrRNA cytidine N-acetyltransferase activity
Molecular FunctiontRNA binding
Molecular FunctiontRNA N-acetyltransferase activity
Biological ProcessrRNA acetylation involved in maturation of SSU-rRNA
Biological ProcesstRNA acetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA cytidine acetyltransferase
  • EC number
  • Alternative names
    • 18S rRNA cytosine acetyltransferase

Gene names

    • ORF names
      LINJ_17_1350

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JPCM5
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    A4HXK2
  • Secondary accessions
    • A0A2K4YRK5
    • A0A381MHJ9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-202tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Domain288-480Helicase
Domain520-774N-acetyltransferase
Domain779-957Possible tRNA binding

Sequence similarities

Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,065
  • Mass (Da)
    116,781
  • Last updated
    2007-05-01 v1
  • Checksum
    93C37709ACCB0467
MVKRKVDDRVKTLIDDIAHHKHRGLILLVGDRAKDQVVNLHLMISRANHNAKVNVLWCMREDPDFGSTGKKQQEKRARLEVKGGLSTEASKEAFQTFLAQTHIRFCKYKETHKILGQTFGMAVLQDFEAINPNTLARTMETVKGGGLIVITFRAMRSLRQLYTIAMDVHARYRTETQRDVVPRFNERFLLSLTDCDTAMCVDDDLNVLPITHKMKSYGKSRKSDAYDADLAVQGRLQHEVDLANVKDTLRPSEDVGPLMQLCQTMDQAKTVLSLMQTVMEKRLDSTCVVTAGRGRGKSAALGMTIAGAIAQGYSNIICTAPTPENVQTLFEFAIRGLKELGYRERTDFEALQGVSEEFAKCFIRINVFREHRQTVQFVSAADTAKFAQAELCVIDEAAALPLTLVKRILGPYLVILSSTVSGYEGTGRSLSMKLVADMRRGSSSGAADARHLKELSMSDPIRYGPGDPVEKWLNKLLCLDATMANTQLTTSPHPSACELFYVNRDALFSYHPLAEELLQRIQSLLVAAHYKNQPNDLQLLSDAPGHHLFVLCADSVESSAATAPTSSTSATAHQQVPDIFCVIHACEEGQVSAQSIKSHLSHGLRPSGDLIPYTLSQYYLEEGFARLAGLRIVRIATNPALPRAGYGSRALSLLHQYYSGSISLTAAEPKTATTKRRSGDSEADARELAGKEHDGDDGEPSAATAMLAPRSHITNLLTPLIERPYELVDYLGTSFGLTTELLNFWKKASYIPLYVRQAPNELTGEHSCIMVRPMGFDLRPLQREFQHRLLPLLAMPFRHLPTELALSLVGDFEAHDPHKMSAAMDLSEVDHHVVRVDGVVQATSDDIAAAFSAGDVQRLRLVSTTFIEGGNVLDLVPTLAKLYFGKQLFRCPDGTDGVVLSHAQAAVLLAVGLQCQTTEELAAQPAFSGVSTQQLRALFLKALSRLSEHLVALQKIAKKAHKDGHNAGVVAGKRARLLSDGAAGDSAAIGGADEDVEDAEEIYDSHGNLKGLKVARKVKAQVCTDRTLLRDASSSISGNASAASTGRDSLQDVFYRPTKKTSKRR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR796449
EMBL· GenBank· DDBJ
CAM59821.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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