A4GRB2 · A4GRB2_CHRID

Function

function

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

123920406080100120140160180200220
TypeIDPosition(s)Description
Binding site96Zn2+ 1 (UniProtKB | ChEBI)
Binding site98Zn2+ 1 (UniProtKB | ChEBI)
Binding site100Zn2+ 2 (UniProtKB | ChEBI)
Binding site159Zn2+ 1 (UniProtKB | ChEBI)
Binding site178Zn2+ 2 (UniProtKB | ChEBI)
Binding site220Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentperiplasmic space
Molecular Functionbeta-lactamase activity
Molecular Functionzinc ion binding
Biological Processantibiotic catabolic process
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Metallo-beta-lactamase type 2
  • EC number
  • Alternative names
    • B2 metallo-beta-lactamase
    • Beta-lactamase type II
    • Metallo-beta-lactamase type II

Gene names

    • Name
      blaIND-7

Organism names

Accessions

  • Primary accession
    A4GRB2

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501082032821-239Metallo-beta-lactamase type 2

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-220Metallo-beta-lactamase

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    239
  • Mass (Da)
    26,829
  • Last updated
    2007-04-17 v1
  • Checksum
    85F1C7A71C3EA656
MKKSIRFFIVSILLSPFASAQVKDFVIEPPIKNNLHIYKTFGVFGGKEYSANSMYLVTKKGVVLFDVPWEKVQYQSLMDTIKKRHNLPVVAVFATHSHDDRAGDLSFFNNKGIKTYATAKTNEFLKKDGKATSTEIIKTGKPYRIGGEEFVVDFLGEGHTADNVVVWFPKYNVLDGGCLVKSNSATDLGYIKEANVEQWPKTINKLKAKYSKATLIIPGHDEWKGGGHVEHTLELLNKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF394437
EMBL· GenBank· DDBJ
ABO21412.1
EMBL· GenBank· DDBJ
Genomic DNA
AB529520
EMBL· GenBank· DDBJ
BAJ05825.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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