A4FUT8 · A4FUT8_HUMAN
- ProteinLysine-specific demethylase
- GeneJMJD1B
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1551 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
Catalytic activity
- 2 2-oxoglutarate + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl9-[histone H3] + 2 succinate
2 CHEBI:16810 + RHEA-COMP:15541 CHEBI:61976 Position: 9+ 2 CHEBI:15379 = 2 CHEBI:16526 + 2 CHEBI:16842 + RHEA-COMP:15546 CHEBI:29969 Position: 9+ 2 CHEBI:30031
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | histone deacetylase complex | |
Molecular Function | chromatin DNA binding | |
Molecular Function | histone H3K9 demethylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription coregulator activity | |
Biological Process | demethylation | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysine-specific demethylase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA4FUT8
Subcellular Location
PTM/Processing
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 43-136 | Disordered | ||||
Sequence: DNSTPQSEGGTLKAVKSSKGKKKRESIEGKDGRRRKSASDSGCDPASKKLKGDRGEVDSNGSDGGEASRGPWKGGNASGEPGLDQRAKQPPSTF | ||||||
Compositional bias | 63-102 | Basic and acidic residues | ||||
Sequence: KKKRESIEGKDGRRRKSASDSGCDPASKKLKGDRGEVDSN | ||||||
Region | 160-184 | Disordered | ||||
Sequence: QDEPVGGDTPASFTPYSTATGQTPL | ||||||
Region | 228-286 | Disordered | ||||
Sequence: DTGLAAGTVPEKQKGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRSQSNGVL | ||||||
Compositional bias | 239-286 | Polar residues | ||||
Sequence: KQKGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRSQSNGVL | ||||||
Region | 362-393 | Disordered | ||||
Sequence: RSVLGTDTKPGSKAGSSVDRKVPAESMPTLTP | ||||||
Region | 504-552 | Disordered | ||||
Sequence: GPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLL | ||||||
Region | 595-618 | Disordered | ||||
Sequence: ACRQDSDSSTNSDLSDLSDSEEQL | ||||||
Compositional bias | 598-618 | Polar residues | ||||
Sequence: QDSDSSTNSDLSDLSDSEEQL | ||||||
Compositional bias | 932-956 | Polar residues | ||||
Sequence: GMSQLPSINPSASSGNETTFSGGGG | ||||||
Region | 932-1010 | Disordered | ||||
Sequence: GMSQLPSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASNSNSELKAIRPPCPDTAPPSS | ||||||
Compositional bias | 968-982 | Basic and acidic residues | ||||
Sequence: VPKADSTDIRSEEPL | ||||||
Domain | 1288-1511 | JmjC | ||||
Sequence: MPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFR |
Domain
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.
Sequence similarities
Belongs to the JHDM2 histone demethylase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,551
- Mass (Da)169,055
- Last updated2007-04-17 v1
- Checksum5DC5AB2875B0BF8A
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: G | ||||||
Compositional bias | 63-102 | Basic and acidic residues | ||||
Sequence: KKKRESIEGKDGRRRKSASDSGCDPASKKLKGDRGEVDSN | ||||||
Compositional bias | 239-286 | Polar residues | ||||
Sequence: KQKGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRSQSNGVL | ||||||
Compositional bias | 598-618 | Polar residues | ||||
Sequence: QDSDSSTNSDLSDLSDSEEQL | ||||||
Compositional bias | 932-956 | Polar residues | ||||
Sequence: GMSQLPSINPSASSGNETTFSGGGG | ||||||
Compositional bias | 968-982 | Basic and acidic residues | ||||
Sequence: VPKADSTDIRSEEPL |
Keywords
- Technical term