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A4FUF2 · A4FUF2_BOVIN

  • Protein
    Elongation of very long chain fatty acids protein 2
  • Gene
    ELOVL2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Catalytic activity

Pathway

Lipid metabolism; polyunsaturated fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionfatty acid elongase activity
Biological Processfatty acid elongation, monounsaturated fatty acid
Biological Processfatty acid elongation, polyunsaturated fatty acid
Biological Processfatty acid elongation, saturated fatty acid
Biological Processsphingolipid biosynthetic process
Biological Processunsaturated fatty acid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation of very long chain fatty acids protein 2
  • EC number
  • Alternative names
    • 3-keto acyl-CoA synthase ELOVL2
    • ELOVL fatty acid elongase 2
      (ELOVL FA elongase 2
      )
    • Very long chain 3-ketoacyl-CoA synthase 2
    • Very long chain 3-oxoacyl-CoA synthase 2

Gene names

    • Name
      ELOVL2

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Crossbred x Angus
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A4FUF2
  • Secondary accessions
    • F1MLC2

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-52Helical
Transmembrane64-84Helical
Transmembrane117-135Helical
Transmembrane147-164Helical
Transmembrane170-192Helical
Transmembrane204-224Helical
Transmembrane230-254Helical

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif291-294Di-lysine motif

Domain

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

Sequence similarities

Belongs to the ELO family. ELOVL2 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    294
  • Mass (Da)
    34,328
  • Last updated
    2007-04-17 v1
  • MD5 Checksum
    5336A19D5708A58F8C8D3B36D39E8B6B
MEHLKAFDDEVNAFLDNMFGPRDSRVRGWFMLDSYLPTFSLTVLYLLLIWLGNRCMRNRPALSLRGILTLYNLGITLLSAYMLAELILSSWEGGYNLQCQDLTSAGEADIRVARVLWWYYFSKLIEFLDTIFFVLRKKTSQVTFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFLLTITHTMSAVVRPCGFPLGCLIFQSSYMMTLVILFLNFYIQTYRKKPMKKAMEEAGKEVKNGFSKAYFSTANGVISKKAQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q1M5H1A0A3Q1M5H1_BOVINELOVL2307

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC114786
EMBL· GenBank· DDBJ
AAI14787.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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