A4FUD0 · A4FUD0_BOVIN

  • Protein
    C-1-tetrahydrofolate synthase, cytoplasmic
  • Gene
    MTHFD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionformate-tetrahydrofolate ligase activity
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NAD+) activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological Process10-formyltetrahydrofolate biosynthetic process
Biological Processheart development
Biological Processmethionine biosynthetic process
Biological Processneural tube closure
Biological Processneutrophil homeostasis
Biological Processpurine ribonucleotide biosynthetic process
Biological Processserine family amino acid biosynthetic process
Biological Processsomite development
Biological Processtetrahydrofolate interconversion
Biological Processtranssulfuration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      MTHFD1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • L1 Hereford
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A4FUD0

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-125Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain129-293Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    935
  • Mass (Da)
    101,177
  • Last updated
    2007-04-17 v1
  • Checksum
    BF41B702ED19850A
MAPAEILNGKVVSAQIKERLKNQVIQMKEEVPGFIPGLAILQVGNRDDSNLYINMKLKAAEEIGIKATHIKLPRTATESEVLKCITSLNEDLTVHGFIVQLPLDSENPINTETLVNAIAPEKDVDGLNSISAGKLARGDLSNCFIPCTPKGCLELIKETGVQIAGRHAVVVGRSKIVGAPMHDLLLWNHATVTTCHSKTANLKEEISKGDILVVAAGQPEMVKGEWIKPGAIVIDCGINYVTDDTKPNGKKIVGDVAYTEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLENFKPGKWIIQYNKLNLKTPVPSDIDISRSYKPKPIGNLAREVGLRTEEVELYGETKAKVLLSALERLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGTHLHQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHEETQTDKALFNRLVPSVNGVRKFSDIQIRRLRRLGIEKTDPATLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHSRTAQFDISVASEIMAVLALTSSLEDMRERLGKMVVASSKKGEPISTEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIEEDLELVGKGFSNLKKQIENARMFGVPVVVAVNAFKTDTEAELDLVSRLAKEHGAFDAVKCTHWAEGGKGALALAEAVQRAAAAPSSFQLLYDLKLPVEDKIRIIAQKIYGADNIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPELKGVPTGFVLPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9SYC7A0AAA9SYC7_BOVINMTHFD1884
A0AAA9TF88A0AAA9TF88_BOVINMTHFD1924
A0AAA9S4R0A0AAA9S4R0_BOVINMTHFD1852
A0A3Q1M478A0A3Q1M478_BOVINMTHFD1934

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC114711
EMBL· GenBank· DDBJ
AAI14712.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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