A4FUD0 · A4FUD0_BOVIN
- ProteinC-1-tetrahydrofolate synthase, cytoplasmic
- GeneMTHFD1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids935 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | formate-tetrahydrofolate ligase activity | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NAD+) activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | 10-formyltetrahydrofolate biosynthetic process | |
Biological Process | heart development | |
Biological Process | methionine biosynthetic process | |
Biological Process | neural tube closure | |
Biological Process | neutrophil homeostasis | |
Biological Process | purine ribonucleotide biosynthetic process | |
Biological Process | serine family amino acid biosynthetic process | |
Biological Process | somite development | |
Biological Process | tetrahydrofolate interconversion | |
Biological Process | transsulfuration |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameC-1-tetrahydrofolate synthase, cytoplasmic
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA4FUD0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-125 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | |||
Domain | 129-293 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | |||
Sequence similarities
In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length935
- Mass (Da)101,177
- Last updated2007-04-17 v1
- ChecksumBF41B702ED19850A
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SYC7 | A0AAA9SYC7_BOVIN | MTHFD1 | 884 | ||
A0AAA9TF88 | A0AAA9TF88_BOVIN | MTHFD1 | 924 | ||
A0AAA9S4R0 | A0AAA9S4R0_BOVIN | MTHFD1 | 852 | ||
A0A3Q1M478 | A0A3Q1M478_BOVIN | MTHFD1 | 934 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC114711 EMBL· GenBank· DDBJ | AAI14712.1 EMBL· GenBank· DDBJ | mRNA |