A3YTM2 · A3YTM2_9SYNE

  • Protein
    7-carboxy-7-deazaguanine synthase
  • Gene
    queE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

S-adenosyl-L-methionine (UniProtKB | Rhea| CHEBI:59789 )

Note: Binds 1 S-adenosyl-L-methionine per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17-19substrate
Binding site32substrate
Binding site36[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site40[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site42-44S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site43[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site45Mg2+ (UniProtKB | ChEBI)
Binding site80substrate
Binding site82S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site129-131S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-nitrogen lyase activity
Molecular Functionmagnesium ion binding
Molecular FunctionS-adenosyl-L-methionine binding
Biological Processqueuosine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-carboxy-7-deazaguanine synthase
  • EC number
  • Short names
    CDG synthase
  • Alternative names
    • Queuosine biosynthesis protein QueE

Gene names

    • Name
      queE
    • ORF names
      WH5701_03910

Organism names

  • Taxonomic identifier
  • Strain
    • WH5701
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Synechococcaceae > Synechococcus

Accessions

  • Primary accession
    A3YTM2

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-218Radical SAM core

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    218
  • Mass (Da)
    23,104
  • Last updated
    2007-04-03 v1
  • Checksum
    13CB5B2CFE038164
MAVPPAGLPVVETFHSLQGEGVHAGRSAFFIRLAGCSVGCSWCDTKHSWPADAHPLCRFQDLAASAALAAAEGAAFVVITGGEPLHHNLDPLCEALRQGSGAGPSPLPLHLETSGVDPLSGRFEWITLSPKRHRPPTAELLAACHELKVVIHEIADLAFAETMAAAVRSACPVKGALPQLLLQPGWGSAAGQELAVQHVRRNPAWRLSLQSHKWLGVR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AANO01000001
EMBL· GenBank· DDBJ
EAQ76383.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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