A3R404 · A3R404_MOUSE

  • Protein
    ATP synthase protein 8
  • Gene
    ATP8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Molecular Functionhydrolase activity
Molecular Functionproton transmembrane transporter activity
Biological Processproton motive force-driven ATP synthesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ATP synthase protein 8

Gene names

    • Name
      ATP8

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • FVB/NJ
    • M17
    • M6
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A3R404

Subcellular Location

Membrane
; Single-pass membrane protein
Mitochondrion membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical

Keywords

PTM/Processing

Keywords

Proteomic databases

Structure

Family & Domains

Sequence similarities

Belongs to the ATPase protein 8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    67
  • Mass (Da)
    7,814
  • Last updated
    2007-04-03 v1
  • Checksum
    49D85AC4FF274E54
MPQLYTSTWFITIISSMITLFILFQLKVSSQTFPLAPSPKSLTTMKVKTPWELKWTKIYLPHSLPQQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF108338
EMBL· GenBank· DDBJ
ABK79201.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675026
EMBL· GenBank· DDBJ
AEN03373.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675027
EMBL· GenBank· DDBJ
AEN03386.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675028
EMBL· GenBank· DDBJ
AEN03399.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675029
EMBL· GenBank· DDBJ
AEN03412.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675030
EMBL· GenBank· DDBJ
AEN03425.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ675031
EMBL· GenBank· DDBJ
AEN03438.1
EMBL· GenBank· DDBJ
Genomic DNA
KP260514
EMBL· GenBank· DDBJ
AJK91490.1
EMBL· GenBank· DDBJ
Genomic DNA
KP260517
EMBL· GenBank· DDBJ
AJK91529.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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