A3QFX1 · FABV_SHELP
- ProteinEnoyl-[acyl-carrier-protein] reductase [NADH]
- GenefabV
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids400 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
Catalytic activity
- a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + NADH + H+
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 48-53 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 74-75 | NAD+ (UniProtKB | ChEBI) | |||
Site | 75 | Plays an important role in discriminating NADH against NADPH | |||
Binding site | 111-112 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 139-140 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 225 | substrate | |||
Active site | 235 | Proton donor | |||
Binding site | 244 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 273-275 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | enoyl-[acyl-carrier-protein] reductase (NADH) activity | |
Molecular Function | NAD binding | |
Molecular Function | trans-2-enoyl-CoA reductase (NADH) activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEnoyl-[acyl-carrier-protein] reductase [NADH]
- EC number
- Short namesENR
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionA3QFX1
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000070500 | 1-400 | Enoyl-[acyl-carrier-protein] reductase [NADH] | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length400
- Mass (Da)43,933
- Last updated2007-04-17 v1
- MD5 Checksum0F055EF68DA3FEA2A092C640AA6D3ADF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000606 EMBL· GenBank· DDBJ | ABO24369.1 EMBL· GenBank· DDBJ | Genomic DNA |