A3MWX6 · SRP54_PYRCJ

Function

function

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site105-112GTP (UniProtKB | ChEBI)
Binding site185-189GTP (UniProtKB | ChEBI)
Binding site243-246GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentsignal recognition particle
Molecular Function7S RNA binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological ProcessSRP-dependent cotranslational protein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal recognition particle 54 kDa protein
  • EC number
  • Short names
    SRP54

Gene names

    • Name
      srp54
    • Ordered locus names
      Pcal_1726

Organism names

Accessions

  • Primary accession
    A3MWX6

Proteomes

Subcellular Location

Cytoplasm
Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003222461-431Signal recognition particle 54 kDa protein

Interaction

Subunit

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

Protein-protein interaction databases

Structure

Family & Domains

Domain

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.

Sequence similarities

Belongs to the GTP-binding SRP family. SRP54 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    431
  • Mass (Da)
    48,296
  • Last updated
    2007-04-03 v1
  • MD5 Checksum
    026A455509FD1C4BE9A7563CB76238B6
MKLSEVFSKLIEKIRGVDYIDEAVLQELSREIQRSLLKADVPLELVKAFTDSAVKRIREEKPPAGIPPREYLVYVLYEELVKLLGGEQPAEFKPTKKPYVVLLLGVEGSGKTTTAAKLAKYLAKRGYKVGLVETDTIRPAAFDQLKQLAEKIGVPFYGERDGKNAVEIAVRGVQNFKNMDVVIIDTAGRHRNEEELLKEVKAIYDAVKPDEVFLVIDATVGKLAAAQAEAFMKYLPIHSVIITKMDSTARGGGALAAVAKTGARVKFIGVGEDVDEFELFNPRKFVARVLGMGDLDALVEKIKAVFEEDKVLEELESGRLDLLTFKKQIDSLLKLGPLSKVFQLLPSNFAIKVSEEQIELSQKNLRKWKAILSSMTMEELKHPEVLNASRIRRIAMGAGVTPKDVKEMLTVFENMKKMSKMLKRQMRMKMR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000561
EMBL· GenBank· DDBJ
ABO09143.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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