A3LUK5 · DUS3_PICST

Function

function

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity).
Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site250-252FMN (UniProtKB | ChEBI)
Binding site305FMN (UniProtKB | ChEBI)
Active site337Proton donor
Binding site377FMN (UniProtKB | ChEBI)
Binding site408FMN (UniProtKB | ChEBI)
Binding site456-458FMN (UniProtKB | ChEBI)
Binding site480-481FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA dihydrouridine synthase activity
Molecular FunctiontRNA-dihydrouridine47 synthase activity
Biological ProcessmRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]
  • EC number
  • Alternative names
    • mRNA-dihydrouridine synthase DUS3 (EC:1.3.1.-
      ) . EC:1.3.1.- (UniProtKB | ENZYME | Rhea)
    • tRNA-dihydrouridine synthase 3

Gene names

    • Name
      DUS3
    • ORF names
      PICST_83606

Organism names

Accessions

  • Primary accession
    A3LUK5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003302471-613tRNA-dihydrouridine47 synthase [NAD(P)+]

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, zinc finger.

TypeIDPosition(s)Description
Region1-24Disordered
Region40-78Disordered
Zinc finger88-111C3H1-type 1
Zinc finger128-149C3H1-type 2

Sequence similarities

Belongs to the Dus family. Dus3 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    613
  • Mass (Da)
    69,682
  • Last updated
    2007-04-03 v1
  • Checksum
    2F1C257CCA755FB8
MTAGEKRTSEALDQPESKKVHVERGMAAIKPEFIVQKDRIVDSFDDDEAEGGERGVEEGKSGKGGKKKRRGQNKNRDLKQKREEIRLCTSLLDPDNIKTCAYGPEQCRSTHNVEEYLASKPVDIEGICPVFRAIGYCPAGLKCRWLQSHYDKETRKLIKDLGRTEASKIELNYEVNNVSHEARGKLRKKQYDFAIAGKVIEYIDSTVQNDENIANAKEQRKNNEATYVDAPYKIAEKKRLDFRNAKIVSPLTTVGNLPYRRLMKKLGADITYSEMALSVPLLQATNAEWALPKAHRTEYPGYGVQIATSKHWAAAKVAEIISRETEHVSELNLNCGCPIDLLYRQGQGSALLEQPARLVRILKAMNASSGDIPVTVKIRTGSKENKNTAKTLVERLLAENDVAAITLHGRSRQQRYTKEADWNYIAEVGQVVQQWNDKKEENKDSRDTQRTCFVGNGDVFSHVDWYNAVNTDGIDSVMVARGALIKPWIFEEVEAQQYLDKTATERLDILKTFSDYALEHWGTDEYGVGLARRFMCEFLSFTHRYIPLGILERLPPKINERPPQWKGRNEMETLLGSTDYKDWIKITEMFLGKSGDDFVFTPKHKSNSYEKSN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000498
EMBL· GenBank· DDBJ
ABN66252.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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