A3KFX0 · 5NT1A_MOUSE

  • Protein
    Cytosolic 5'-nucleotidase 1A
  • Gene
    Nt5c1a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (By similarity).
AMP is the major substrate but can also hydrolyze dCMP and IMP (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by ADP.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site208Nucleophile

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function5'-nucleotidase activity
Molecular FunctionIMP 5'-nucleotidase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Molecular FunctionXMP 5'-nucleosidase activity
Biological Processadenosine metabolic process
Biological Processallantoin metabolic process
Biological Processamide catabolic process
Biological ProcessAMP catabolic process
Biological ProcessdAMP catabolic process
Biological ProcessdGMP catabolic process
Biological ProcessIMP catabolic process
Biological Processpurine nucleoside monophosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytosolic 5'-nucleotidase 1A
  • EC number
  • Short names
    cN1A
  • Alternative names
    • 5'-deoxynucleotidase
    • Cytosolic 5'-nucleotidase IA (cN-IA)

Gene names

    • Name
      Nt5c1a

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A3KFX0
  • Secondary accessions
    • B2RVQ9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003049301-365Cytosolic 5'-nucleotidase 1A

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-23Disordered

Sequence similarities

Belongs to the 5'-nucleotidase type 3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    40,678
  • Last updated
    2007-04-03 v1
  • Checksum
    10DBCBE793C69D64
MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL606934
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466552
EMBL· GenBank· DDBJ
EDL30387.1
EMBL· GenBank· DDBJ
Genomic DNA
BC147308
EMBL· GenBank· DDBJ
AAI47309.1
EMBL· GenBank· DDBJ
mRNA
BC147309
EMBL· GenBank· DDBJ
AAI47310.1
EMBL· GenBank· DDBJ
mRNA
BC147730
EMBL· GenBank· DDBJ
AAI47731.1
EMBL· GenBank· DDBJ
mRNA
BC147733
EMBL· GenBank· DDBJ
AAI47734.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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