A3KFX0 · 5NT1A_MOUSE
- ProteinCytosolic 5'-nucleotidase 1A
- GeneNt5c1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids365 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (By similarity).
AMP is the major substrate but can also hydrolyze dCMP and IMP (By similarity).
AMP is the major substrate but can also hydrolyze dCMP and IMP (By similarity).
Catalytic activity
- a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate
- AMP + H2O = adenosine + phosphate
- dCMP + H2O = 2'-deoxycytidine + phosphate
Cofactor
Activity regulation
Activated by ADP.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 208 | Nucleophile | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 5'-nucleotidase activity | |
Molecular Function | IMP 5'-nucleotidase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | XMP 5'-nucleosidase activity | |
Biological Process | adenosine metabolic process | |
Biological Process | allantoin metabolic process | |
Biological Process | amide catabolic process | |
Biological Process | AMP catabolic process | |
Biological Process | dAMP catabolic process | |
Biological Process | dGMP catabolic process | |
Biological Process | IMP catabolic process | |
Biological Process | purine nucleoside monophosphate catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytosolic 5'-nucleotidase 1A
- EC number
- Short namescN1A
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA3KFX0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000304930 | 1-365 | Cytosolic 5'-nucleotidase 1A | |||
Sequence: MEPGQPREAREPGPGAETAAVPRWEEAKTFYDNLSSKKKPKSPKPQNAVTIAVSSRALFRMDEEQRIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNKRLRELYPDSEDIFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADADKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQNPRRAAAAKQSLGAQ |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MEPGQPREAREPGPGAETAAVPR |
Sequence similarities
Belongs to the 5'-nucleotidase type 3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)40,678
- Last updated2007-04-03 v1
- Checksum10DBCBE793C69D64
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL606934 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466552 EMBL· GenBank· DDBJ | EDL30387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC147308 EMBL· GenBank· DDBJ | AAI47309.1 EMBL· GenBank· DDBJ | mRNA | ||
BC147309 EMBL· GenBank· DDBJ | AAI47310.1 EMBL· GenBank· DDBJ | mRNA | ||
BC147730 EMBL· GenBank· DDBJ | AAI47731.1 EMBL· GenBank· DDBJ | mRNA | ||
BC147733 EMBL· GenBank· DDBJ | AAI47734.1 EMBL· GenBank· DDBJ | mRNA |