A3GGE9 · DBP4_PICST

Function

function

ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).

Catalytic activity

Features

Showing features for binding site.

1765100200300400500600700
TypeIDPosition(s)Description
Binding site91-98ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent RNA helicase DBP4
  • EC number

Gene names

    • Name
      DBP4
    • ORF names
      PICST_51414

Organism names

Accessions

  • Primary accession
    A3GGE9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002851411-765ATP-dependent RNA helicase DBP4

Interaction

Subunit

Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif, domain, compositional bias.

TypeIDPosition(s)Description
Region1-24Disordered
Motif47-75Q motif
Domain78-252Helicase ATP-binding
Motif200-203DEAD box
Domain266-438Helicase C-terminal
Region493-526Disordered
Compositional bias501-516Polar residues
Region552-576Disordered
Compositional bias641-669Basic and acidic residues
Region641-735Disordered
Compositional bias716-735Basic and acidic residues

Domain

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    765
  • Mass (Da)
    87,257
  • Last updated
    2010-01-19 v2
  • Checksum
    E581A5E1A0AF8379
MAKPRRNNKNKKGQSRSQAREKEEAELLKLQERIDQYDPAVDEKSISQFSDLPITQETLRGLNESSFMSLTDIQKKTIPIALKGEDLMGTARTGSGKTLAFLIPVVESLIRNKITEHDGLAALIVSPTRELAVQTFEVLTKIGKYNTFSAGLVTGGKDVQYEKERVSRMNILVGTPGRISQHLNEAVGMETSNLQVLVLDEADRCLDMGFKKQIDNIVGHLPPTRQTLLFSATVSDSVKDLARLSLTNPKRIGVSSDQDVSATPESLDQYYIRIPLDEKLDVLWSFIKSHLKSKILVFFSSSKQVQYAYETFRTLQPGISLLKLYGRHKQTSRLETTVKFTQAQYACLFATDIVARGLDFPAIDWVVQVDCPEDAVTYVHRVGRAARFGRQGKSLLMLLPSEEEGMLKRLENNKIEPKFMNIKQKSKKSIRPQLQSLCFKDPMIKNLGQRAFISYYKSVYIQKDKDVFKVEELPSEKYAASLGLPGAPKIKIKGGSSSKEKKNASRQLVALSKTNEDGESVENEASKVRTKYDRMFERKNQNVLSEHYLKLNGSQTKEDEDEEEEDDFMSVKRKDHELTEVELPDLTIPVSKRQAKKALSKKLSISTKGNPTKLKFDDEGVAHAIYELEDEEDFIKRGDAKEQKKAFVSRETEVMNEADEEDKIMAKEKRQEKKRKRKEVEKRMRDEELQSGDDEETVYTLGGDVDLERDMEYSTDEEEQPQNKKPKWFENDKHNRKNPVNHIVEIDEPETLEDLESLTARLLQH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias501-516Polar residues
Compositional bias641-669Basic and acidic residues
Compositional bias716-735Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAVQ01000001
EMBL· GenBank· DDBJ
EAZ63509.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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