A3DM85 · PRIS_STAMF

Function

function

Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site.

137750100150200250300350
TypeIDPosition(s)Description
Active site99
Active site101
Active site274

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Cellular Componentprimosome complex
Molecular FunctionDNA primase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA primase small subunit PriS
  • EC number

Gene names

    • Name
      priS
    • Synonyms
      priA
    • Ordered locus names
      Smar_0639

Organism names

Accessions

  • Primary accession
    A3DM85

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001323481-377DNA primase small subunit PriS

Interaction

Subunit

Heterodimer of a small subunit (PriS) and a large subunit (PriL).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the eukaryotic-type primase small subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    377
  • Mass (Da)
    43,866
  • Last updated
    2007-03-20 v1
  • Checksum
    219CC7886169CABD
MSRQESSNKFFIKKILREYYSRKPLEEPLYIHKREIAIHSLEDEAYIRHLSFPSITHLYNFILNEKTPLHLYYSSAYYESPSVNKMELKGWIGSDLMFDLDSDHYPGCDKILSICIEENTIYDGKIKTCPKTESKPVIHPLIKTECIQKAYRDALRIKYILEDELGLKNIKIYFSGNRGFHVKVIDEKIWDLESDERREIASYISLENFDINKLFPVIGKRKKYVIITRNEHGIRKRVLDYVIKNNIVNGNELFIKLPLKLLEETINDLTIPIDIVVTMDISRLSRFGNSINGKSGLITKLIEPLDNYEFDINDFCPWSGNIVVKPLIDISGLQVFDEKIDLKRGVKKILDSKIAVYLTLKGIVKIISDEKLVIKNV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000575
EMBL· GenBank· DDBJ
ABN69745.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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