A3DD79 · RNH_ACET2

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.

Features

Showing features for binding site.

114720406080100120140
TypeIDPosition(s)Description
Binding site9Mg2+ 1 (UniProtKB | ChEBI)
Binding site9Mg2+ 2 (UniProtKB | ChEBI)
Binding site47Mg2+ 1 (UniProtKB | ChEBI)
Binding site69Mg2+ 1 (UniProtKB | ChEBI)
Binding site134Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease H
  • EC number
  • Short names
    RNase H

Gene names

    • Name
      rnhA
    • Ordered locus names
      Cthe_0673

Organism names

Accessions

  • Primary accession
    A3DD79

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003325831-147Ribonuclease H

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-142RNase H type-1

Sequence similarities

Belongs to the RNase H family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    147
  • Mass (Da)
    16,913
  • Last updated
    2007-03-20 v1
  • Checksum
    441625A11CC0CFAF
MKKVSIYTDGACSGNPGDGGWGAILIYGNHEKEVSGFEKDTTNNRMELVAAINALKMLKEPCEVDLYSDSAYLVNGFLQNWVEKWKKNGWKTSNKEEVKNMELWQELDRLSNIHKIRWIKVKGHSDNEYNNRCDKLATDEIKKNSKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000568
EMBL· GenBank· DDBJ
ABN51908.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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