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A3CRC6 · A3CRC6_STRSV

Function

function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Activity regulation

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

Pathway

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site253NAD+ (UniProtKB | ChEBI)
Binding site253-255NAD+ (UniProtKB | ChEBI)
Binding site303-305NAD+ (UniProtKB | ChEBI)
Binding site305K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site307K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site308IMP (UniProtKB | ChEBI)
Active site310Thioimidate intermediate
Binding site310K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site343-345IMP (UniProtKB | ChEBI)
Binding site366-367IMP (UniProtKB | ChEBI)
Binding site390-394IMP (UniProtKB | ChEBI)
Active site406Proton acceptor
Binding site421IMP (UniProtKB | ChEBI)
Binding site475K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site476K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site477K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners

GO annotations

AspectTerm
Molecular FunctionIMP dehydrogenase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP biosynthetic process
Biological ProcessGTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine-5'-monophosphate dehydrogenase
  • EC number
  • Short names
    IMP dehydrogenase
    ; IMPD
    ; IMPDH

Gene names

    • Name
      guaB
    • Ordered locus names
      SSA_2374

Organism names

Accessions

  • Primary accession
    A3CRC6

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain97-155CBS
Domain159-219CBS

Sequence similarities

Belongs to the IMPDH/GMPR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    52,695
  • Last updated
    2007-03-20 v1
  • MD5 Checksum
    A7FAF65177D7EB5DDD0C3AF8FDDAE329
MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLSTKLAENLTLNIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIEQQADEVRKVKRSENGVIIDPFFLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYDQPISRHMTSENLVTAPVGTDLGTAERILQEHRIEKLPLVDDNGCLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRSHFPDRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVARKYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMLGGIRSGMGYVGAANLQELHDNAQFIEMSGAGLKESHPHDVQITNEAPNYSVQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000387
EMBL· GenBank· DDBJ
ABN45731.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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