A3AWW3 · A3AWW3_ORYSJ
- ProteinAlpha-1,3/1,6-mannosyltransferase ALG2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids418 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Mannosylates Man2GlcNAc2-dolichol diphosphate and Man1GlcNAc2-dolichol diphosphate to form Man3GlcNAc2-dolichol diphosphate.
Catalytic activity
- an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+This reaction proceeds in the forward direction.
an α-D-Man-(1→3)-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19513 + CHEBI:57527 = an α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol RHEA-COMP:19515 + CHEBI:58189 + CHEBI:15378 - a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H+This reaction proceeds in the forward direction.
Pathway
Protein modification; protein glycosylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity | |
Molecular Function | GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-1,3/1,6-mannosyltransferase ALG2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionA3AWW3
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 86-110 | Helical | ||||
Sequence: IFYRFHAICAYLRCIFVAMCVLLWW |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 31-189 | Glycosyltransferase subfamily 4-like N-terminal | ||||
Sequence: IGGAERLIVDAACQLAVHGHDVHVFTSHHDKNRCFEETVSGPFEVKVYGDFLPRHIFYRFHAICAYLRCIFVAMCVLLWWPSFDIILVDQVSVVIPLLKLKAKSKIVFYCHFPDMLLAQHTTMLRRLYRKPIDMIEETTTGMADLILVNSKFTATTFAR | ||||||
Domain | 222-389 | Glycosyl transferase family 1 | ||||
Sequence: NFLSINRFERKKNLGLAISAFSLLRSVASMLPGDARQEVTLTVAGGYDKRLRENVEYLEELKRLAASEGVSEHVKFVTSCSTSERNELLSNCLCVLYTPKDEHFGIVPLEAMAAYKPVIACNSGGPVETVINDETGFLCEPSAPEFSKAMLKLVNDHDLAVKMGKQAR |
Sequence similarities
Belongs to the glycosyltransferase group 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length418
- Mass (Da)46,584
- Last updated2020-02-26 v1
- ChecksumC97286C709141DF3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP008210 EMBL· GenBank· DDBJ | BAF15613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL662981 EMBL· GenBank· DDBJ | CAE04862.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM000141 EMBL· GenBank· DDBJ | EAZ31802.1 EMBL· GenBank· DDBJ | Genomic DNA |