A2Y533 · H32_ORYSI

Function

function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Caution

To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me = methylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me = methylated Lys-10; H3S10ph = phosphorylated Ser-11; H3T11ph = phosphorylated Thr-12; H3K14ac = acetylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me = methylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me = methylated Lys-24; H3K27me = methylated Lys-28; H3S28ph = phosphorylated Ser-29; H3K36me = methylated Lys-37.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Molecular Functionstructural constituent of chromatin

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone H3.2

Gene names

    • ORF names
      OsI_019426
    • ORF names
      OsI_021009
    • ORF names
      OsI_021012
    • ORF names
      OsI_033964

Organism names

  • Taxonomic identifier
  • Strains
    • cv. IR26
    • cv. Milyang 23
    • cv. 93-11
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    A2Y533
  • Secondary accessions
    • P05203
    • P05329
    • P05330
    • P08860
    • P69247

Proteomes

    • Identifier
    • Component
      Chromosome 11, Chromosome 5, Chromosome 6

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain, modified residue.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00002956542-136Histone H3.2
Modified residue5N6-methylated lysine
Modified residue10N6-acetyllysine; alternate
Modified residue10N6-methylated lysine; alternate
Modified residue11Phosphoserine
Modified residue12Phosphothreonine
Modified residue15N6-acetyllysine
Modified residue19N6-acetyllysine; alternate
Modified residue19N6-methylated lysine; alternate
Modified residue24N6-acetyllysine; alternate
Modified residue24N6-methylated lysine; alternate
Modified residue28N6-methylated lysine
Modified residue29Phosphoserine
Modified residue37N6-methylated lysine

Post-translational modification

Acetylation is generally linked to gene activation. Can be acetylated to form H3K9ac, H3K14ac, H3K18ac and H3K23ac. H3K9ac could compete with H3K9me and prevent gene silencing. H3K9ac is restricted to euchromatin (By similarity).
Methylated to form mainly H3K4me, H3K9me, H3K18me, H3K23me, H3K27me and H3K36me. H3K4me1/2/3, H3K9me3, H3K27me3 and H3K36me1/2/3 are typical marks for euchromatin, whereas heterochromatic chromocenters are enriched in H3K9me1/2 and H3K27me1/2. H2BK143ub1 is probably prerequisite for H3K4me (By similarity).
Can be phosphorylated to form H3S10ph, H3T11ph and H3S28ph.

Keywords

Expression

Gene expression databases

Interaction

Subunit

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-43Disordered

Sequence similarities

Belongs to the histone H3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    136
  • Mass (Da)
    15,268
  • Last updated
    2007-03-20 v1
  • Checksum
    F1FB03A849777A61
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
B8B1H8B8B1H8_ORYSISYUU0025A11.34136

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict87in Ref. 1; AAA74190
Sequence conflict91in Ref. 1; AAA74190
Sequence conflict99in Ref. 1; AAA74190

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U25664
EMBL· GenBank· DDBJ
AAA74190.1
EMBL· GenBank· DDBJ
Genomic DNA
U77296
EMBL· GenBank· DDBJ
AAB18816.1
EMBL· GenBank· DDBJ
mRNA
CM000130
EMBL· GenBank· DDBJ
EAY98193.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000131
EMBL· GenBank· DDBJ
EAY99776.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000131
EMBL· GenBank· DDBJ
EAY99779.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000136
EMBL· GenBank· DDBJ
EAY80005.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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