A2TLT4 · A2TLT4_9EUCA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids165 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Dendrobranchiata > Penaeoidea > Penaeidae > Penaeus
Accessions
- Primary accessionA2TLT4
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 25-48 | Helical | ||||
Sequence: AHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 113-134 | Helical | ||||
Sequence: FSLHLAGVSSILGAVNFMTTVI | ||||||
Transmembrane | 146-164 | Helical | ||||
Sequence: MPLFVWAVFITALLLLLSL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-165 | Cytochrome oxidase subunit I profile | ||||
Sequence: IIRAELGQPGSLIGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLSSGMVESGVGTGWTVYPPLSASIAHAGASVDLGIFSLHLAGVSSILGAVNFMTTVINMRSTGMTMDRMPLFVWAVFITALLLLLSLP |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length165
- Mass (Da)17,690
- Last updated2007-03-06 v1
- Checksum7DCC58FE2C83AD92
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: I | ||||||
Non-terminal residue | 165 | |||||
Sequence: P |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF219280 EMBL· GenBank· DDBJ | ABN09672.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219281 EMBL· GenBank· DDBJ | ABN09673.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219282 EMBL· GenBank· DDBJ | ABN09674.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219283 EMBL· GenBank· DDBJ | ABN09675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219285 EMBL· GenBank· DDBJ | ABN09677.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219286 EMBL· GenBank· DDBJ | ABN09678.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219287 EMBL· GenBank· DDBJ | ABN09679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219288 EMBL· GenBank· DDBJ | ABN09680.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219289 EMBL· GenBank· DDBJ | ABN09681.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219290 EMBL· GenBank· DDBJ | ABN09682.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219295 EMBL· GenBank· DDBJ | ABN09687.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219296 EMBL· GenBank· DDBJ | ABN09688.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219297 EMBL· GenBank· DDBJ | ABN09689.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219299 EMBL· GenBank· DDBJ | ABN09691.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219301 EMBL· GenBank· DDBJ | ABN09693.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219302 EMBL· GenBank· DDBJ | ABN09694.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219303 EMBL· GenBank· DDBJ | ABN09695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219305 EMBL· GenBank· DDBJ | ABN09697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219306 EMBL· GenBank· DDBJ | ABN09698.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219307 EMBL· GenBank· DDBJ | ABN09699.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219308 EMBL· GenBank· DDBJ | ABN09700.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219310 EMBL· GenBank· DDBJ | ABN09702.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219311 EMBL· GenBank· DDBJ | ABN09703.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219312 EMBL· GenBank· DDBJ | ABN09704.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219313 EMBL· GenBank· DDBJ | ABN09705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219314 EMBL· GenBank· DDBJ | ABN09706.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219315 EMBL· GenBank· DDBJ | ABN09707.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219316 EMBL· GenBank· DDBJ | ABN09708.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219318 EMBL· GenBank· DDBJ | ABN09710.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219319 EMBL· GenBank· DDBJ | ABN09711.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219320 EMBL· GenBank· DDBJ | ABN09712.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219321 EMBL· GenBank· DDBJ | ABN09713.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219322 EMBL· GenBank· DDBJ | ABN09714.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219323 EMBL· GenBank· DDBJ | ABN09715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219324 EMBL· GenBank· DDBJ | ABN09716.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219325 EMBL· GenBank· DDBJ | ABN09717.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219326 EMBL· GenBank· DDBJ | ABN09718.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219327 EMBL· GenBank· DDBJ | ABN09719.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219328 EMBL· GenBank· DDBJ | ABN09720.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219329 EMBL· GenBank· DDBJ | ABN09721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219330 EMBL· GenBank· DDBJ | ABN09722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219331 EMBL· GenBank· DDBJ | ABN09723.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219332 EMBL· GenBank· DDBJ | ABN09724.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219333 EMBL· GenBank· DDBJ | ABN09725.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219334 EMBL· GenBank· DDBJ | ABN09726.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219335 EMBL· GenBank· DDBJ | ABN09727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219336 EMBL· GenBank· DDBJ | ABN09728.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219337 EMBL· GenBank· DDBJ | ABN09729.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219338 EMBL· GenBank· DDBJ | ABN09730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219339 EMBL· GenBank· DDBJ | ABN09731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219340 EMBL· GenBank· DDBJ | ABN09732.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF219341 EMBL· GenBank· DDBJ | ABN09733.1 EMBL· GenBank· DDBJ | Genomic DNA |