A2TLT4 · A2TLT4_9EUCA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Abdijan
    • Amvrakikos
    • Annaba
    • Aquatina
    • Dakar
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Dendrobranchiata > Penaeoidea > Penaeidae > Penaeus

Accessions

  • Primary accession
    A2TLT4

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-48Helical
Transmembrane113-134Helical
Transmembrane146-164Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-165Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    165
  • Mass (Da)
    17,690
  • Last updated
    2007-03-06 v1
  • Checksum
    7DCC58FE2C83AD92
IIRAELGQPGSLIGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLSSGMVESGVGTGWTVYPPLSASIAHAGASVDLGIFSLHLAGVSSILGAVNFMTTVINMRSTGMTMDRMPLFVWAVFITALLLLLSLP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue165

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF219280
EMBL· GenBank· DDBJ
ABN09672.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219281
EMBL· GenBank· DDBJ
ABN09673.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219282
EMBL· GenBank· DDBJ
ABN09674.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219283
EMBL· GenBank· DDBJ
ABN09675.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219285
EMBL· GenBank· DDBJ
ABN09677.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219286
EMBL· GenBank· DDBJ
ABN09678.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219287
EMBL· GenBank· DDBJ
ABN09679.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219288
EMBL· GenBank· DDBJ
ABN09680.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219289
EMBL· GenBank· DDBJ
ABN09681.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219290
EMBL· GenBank· DDBJ
ABN09682.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219295
EMBL· GenBank· DDBJ
ABN09687.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219296
EMBL· GenBank· DDBJ
ABN09688.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219297
EMBL· GenBank· DDBJ
ABN09689.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219299
EMBL· GenBank· DDBJ
ABN09691.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219301
EMBL· GenBank· DDBJ
ABN09693.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219302
EMBL· GenBank· DDBJ
ABN09694.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219303
EMBL· GenBank· DDBJ
ABN09695.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219305
EMBL· GenBank· DDBJ
ABN09697.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219306
EMBL· GenBank· DDBJ
ABN09698.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219307
EMBL· GenBank· DDBJ
ABN09699.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219308
EMBL· GenBank· DDBJ
ABN09700.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219310
EMBL· GenBank· DDBJ
ABN09702.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219311
EMBL· GenBank· DDBJ
ABN09703.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219312
EMBL· GenBank· DDBJ
ABN09704.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219313
EMBL· GenBank· DDBJ
ABN09705.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219314
EMBL· GenBank· DDBJ
ABN09706.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219315
EMBL· GenBank· DDBJ
ABN09707.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219316
EMBL· GenBank· DDBJ
ABN09708.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219318
EMBL· GenBank· DDBJ
ABN09710.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219319
EMBL· GenBank· DDBJ
ABN09711.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219320
EMBL· GenBank· DDBJ
ABN09712.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219321
EMBL· GenBank· DDBJ
ABN09713.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219322
EMBL· GenBank· DDBJ
ABN09714.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219323
EMBL· GenBank· DDBJ
ABN09715.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219324
EMBL· GenBank· DDBJ
ABN09716.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219325
EMBL· GenBank· DDBJ
ABN09717.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219326
EMBL· GenBank· DDBJ
ABN09718.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219327
EMBL· GenBank· DDBJ
ABN09719.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219328
EMBL· GenBank· DDBJ
ABN09720.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219329
EMBL· GenBank· DDBJ
ABN09721.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219330
EMBL· GenBank· DDBJ
ABN09722.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219331
EMBL· GenBank· DDBJ
ABN09723.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219332
EMBL· GenBank· DDBJ
ABN09724.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219333
EMBL· GenBank· DDBJ
ABN09725.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219334
EMBL· GenBank· DDBJ
ABN09726.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219335
EMBL· GenBank· DDBJ
ABN09727.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219336
EMBL· GenBank· DDBJ
ABN09728.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219337
EMBL· GenBank· DDBJ
ABN09729.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219338
EMBL· GenBank· DDBJ
ABN09730.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219339
EMBL· GenBank· DDBJ
ABN09731.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219340
EMBL· GenBank· DDBJ
ABN09732.1
EMBL· GenBank· DDBJ
Genomic DNA
EF219341
EMBL· GenBank· DDBJ
ABN09733.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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