A2SLH5 · TRPD_METPP

Function

function

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per monomer.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site835-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site83anthranilate 1 (UniProtKB | ChEBI)
Binding site86-875-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site915-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site93-965-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site95Mg2+ 1 (UniProtKB | ChEBI)
Binding site111-1195-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1235-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site169anthranilate 2 (UniProtKB | ChEBI)
Binding site228Mg2+ 2 (UniProtKB | ChEBI)
Binding site229Mg2+ 1 (UniProtKB | ChEBI)
Binding site229Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionanthranilate phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processtryptophan biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anthranilate phosphoribosyltransferase
  • EC number

Gene names

    • Name
      trpD
    • Ordered locus names
      Mpe_A3461

Organism names

Accessions

  • Primary accession
    A2SLH5

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003254341-344Anthranilate phosphoribosyltransferase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the anthranilate phosphoribosyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    344
  • Mass (Da)
    36,128
  • Last updated
    2007-03-06 v1
  • Checksum
    97CD552D30CF91A1
MITDTAALQRTIEHREIFHDEMLHLMRRIMSGEMSPVMIAALAVGLRVKKESIGEIAAAATVMREFATPVPVADTEHLVDLCGTGGDAAHTFNISTTAMFVAAAAGARVAKHGGRSVSSTSGSADVLEALGASIDLAPAQVAECLAESGIGFMFAPNHHPAMKHAGPVRKELGVRTIFNILGPLTNPAGAPNQLMGVFHPDLVGIQVRVLQRLGSRHVLVVYGMNGMDEISLSGETLIGELKDGEVREYTVHPSDFGLPVYDTRGLKVASKDESVGCIRRALADEAGPVRDIVLLNAGAALYAADVAPSIGEGVRQAREAVASGAAAKTLERFVATTRRLKGAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000555
EMBL· GenBank· DDBJ
ABM96414.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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