A2SLC9 · A2SLC9_METPP
- ProteinThiol:disulfide interchange protein DsbD
- GenedsbD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids623 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Catalytic activity
- [protein]-dithiol + NAD+ = [protein]-disulfide + H+ + NADH
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | electron transfer activity | |
Molecular Function | protein-disulfide reductase (NAD(P)H) activity | |
Biological Process | cell redox homeostasis | |
Biological Process | cytochrome complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThiol:disulfide interchange protein DsbD
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sphaerotilaceae > Methylibium
Accessions
- Primary accessionA2SLC9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 196-220 | Helical | ||||
Sequence: FWLVVFAFFVAGLLLSFTPCVLPML | ||||||
Transmembrane | 241-265 | Helical | ||||
Sequence: LLLAGAYSLGMALVYTALGVAAGLA | ||||||
Transmembrane | 277-300 | Helical | ||||
Sequence: WVLGAFSLLLTLLALSMFGAYELQ | ||||||
Transmembrane | 321-350 | Helical | ||||
Sequence: LAGVFAMGGVSALIVSPCVAAPLAGALLYI | ||||||
Transmembrane | 362-386 | Helical | ||||
Sequence: ALFSLAAGMSVPLLLLGASAGALLP | ||||||
Transmembrane | 398-415 | Helical | ||||
Sequence: FFGLLLLAVAWWMLSPVV | ||||||
Transmembrane | 421-439 | Helical | ||||
Sequence: VAGWGVLLIGAAVFLHAFD | ||||||
Transmembrane | 451-472 | Helical | ||||
Sequence: LVKGLGLALAVAGATQIVGAAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MPPVTPIRFLRTLLLWLTALLPLFAAA | ||||||
Chain | PRO_5009006617 | 28-623 | Thiol:disulfide interchange protein DsbD | |||
Sequence: AEDFLPPEQAFRFDARVLDGKSIEIGFVVADGYYLYREPFKFEAQGGGVVLGAPEIPSGTVKFDETFEKDVETYRGRVAIRLPVDAAPASFQLVVTSQGCADQGLCYPPMQSVADVRLAGFGGDGSVRVPADGRGLDGALAASRASASMAGASRSGDAAIDHALRSGRFWLVVFAFFVAGLLLSFTPCVLPMLPILSSLIVGQGGQAVARSRGLLLAGAYSLGMALVYTALGVAAGLAGEGLAAALQNAWVLGAFSLLLTLLALSMFGAYELQLPAVLRDRLAASSGRLQGGRLAGVFAMGGVSALIVSPCVAAPLAGALLYISQTRDVLLGGSALFSLAAGMSVPLLLLGASAGALLPRAGAWMESVKRFFGLLLLAVAWWMLSPVVPAPLAVAGWGVLLIGAAVFLHAFDRLPEIAGADLRLVKGLGLALAVAGATQIVGAAAGAQDALKPLQPFVVGISPAAAAALPGNAIAATHDGVSFRRVSTVEELDAAVRGAGRPVMLDFYADWCVSCKEMERFTFTDPAVQARLGKALLLQADVTRNSESDRALLKRFQLFGPPGIVFFDAGGRELETRVIGFQNAQRFQQSLQSAGL | ||||||
Disulfide bond | 127↔133 | Redox-active | ||||
Sequence: CADQGLC | ||||||
Disulfide bond | 539↔542 | Redox-active | ||||
Sequence: CVSC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 490-623 | Thioredoxin | ||||
Sequence: PAAAAALPGNAIAATHDGVSFRRVSTVEELDAAVRGAGRPVMLDFYADWCVSCKEMERFTFTDPAVQARLGKALLLQADVTRNSESDRALLKRFQLFGPPGIVFFDAGGRELETRVIGFQNAQRFQQSLQSAGL |
Sequence similarities
Belongs to the thioredoxin family. DsbD subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length623
- Mass (Da)64,842
- Last updated2007-03-06 v1
- ChecksumA319E94EAF79EC77
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000555 EMBL· GenBank· DDBJ | ABM96368.1 EMBL· GenBank· DDBJ | Genomic DNA |