A2SHP5 · A2SHP5_METPP

Function

function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site245Mg2+ (UniProtKB | ChEBI)
Binding site275Mg2+ (UniProtKB | ChEBI)
Binding site277Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionpyruvate dehydrogenase (acetyl-transferring) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate dehydrogenase E1 component
  • EC number

Gene names

    • Ordered locus names
      Mpe_A2128

Organism names

Accessions

  • Primary accession
    A2SHP5

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain117-306Transketolase N-terminal
Domain376-440Transketolase N-terminal
Domain500-715Pyruvate dehydrogenase E1 component middle
Domain728-866Transketolase-like C-terminal

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    909
  • Mass (Da)
    101,322
  • Last updated
    2007-03-06 v1
  • Checksum
    D5523E5D89A07E1E
MSALPESFGRSAANDSDAQETREWLEALAAVIDSEGPQRAHFLLERLIDEARQAGIDMPFSATTPYVNTIPAGQELHSPGQIDIEERLRAYMRWNAMAMVVKANRLDPADGGDLGGHISSFASLATMFGAGFNHFWHADDTDQGGKHGGDLLYIQGHSSPGIYARAFMEGRITEEQLLNFRQEVDGKGLSSYPHPKLMPEFWQFPTVSMGLGPLMAIYQARFLKYLHARGIADTSKRKVWVFCGDGEMDEPESLGAIGLAAREKLDNLIFVINCNLQRLDGPVRGNGKIIQELEGEFRGSGWNVIKLIWGSYWDPLLARDKEGLLRKVMMETVDGDYQAMKANDGAFVRKHFFGQHPKLLEMVSKLSDDDIWRLNRGGHDPHKVHAAYHEAVNHKGQPTVLLIKTVKGYGMGKIGEGKNTAHQTKKLVDEDVKAFRDRFNIPIPDDKLHDIPFYKPADDTPEMQYLHERRKALGGYLPKRRPKADEQLPVPDLSVFQAVMEPTAEGREISTTQAYVRCLNALLRDKALGPRTVPILVDEARTFGMEGLFRQIGIYNPAGQQYTPVDKDQVMYYKEDKAGQILQEGINEAGGMSSWIAAATSYSTNNRIMIPFYIYYSMFGLQRVGDLCWAAGDMQARGFLLGGTSGRTTLNGEGLQHEDGHSHILASTIPNCISYDPTFAHEVAVIIHHGLKRMVEQQDNVYFYLTLLNENYAQPGLRPGTETQIVKGMYLLLEGGSKKKDAPQVNLLGSGTILRESIAAKELLEKDWGVSANVWSCPSFNELARDGQDADRWNLLHPADKKPRVPFVTQQLEPHAGPVVASTDYMKAYAEQIRAFIPKGRSYKVLGTDGFGRSDFRTKLREHFEVNRHYVVVAALKALADEGTVPAAKVAEAIKKYGINADKINPLYA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000555
EMBL· GenBank· DDBJ
ABM95084.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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