A2SH88 · A2SH88_METPP
- ProteinUDP-3-O-acylglucosamine N-acyltransferase
- GenelpxD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids365 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Catalytic activity
- a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H+ + holo-[ACP]
Pathway
Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 247 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | N-acyltransferase activity | |
Biological Process | lipid A biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-3-O-acylglucosamine N-acyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Sphaerotilaceae > Methylibium
Accessions
- Primary accessionA2SH88
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-94 | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region | ||||
Sequence: LDIARIGPLEDADAATISFLANPRYRAQLAGSSAGCVIVAPALRDEAVARGAAIVTPDPYLYFARLTQW | ||||||
Region | 342-365 | Disordered | ||||
Sequence: ERQAAAASDQEPGAADANGAENTP |
Sequence similarities
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)37,353
- Last updated2007-03-06 v1
- ChecksumC190DF648D2FE32C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000555 EMBL· GenBank· DDBJ | ABM94927.1 EMBL· GenBank· DDBJ | Genomic DNA |