A2RSS9 · A2RSS9_MOUSE

  • Protein
    Appetite-regulating hormone
  • Gene
    Ghrl
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentextracellular space
Cellular Componentglutamatergic synapse
Cellular Componentpostsynapse
Cellular ComponentSchaffer collateral - CA1 synapse
Molecular Functionghrelin receptor binding
Molecular Functiongrowth hormone-releasing hormone activity
Molecular Functionprotein tyrosine kinase activator activity
Biological Processactin polymerization or depolymerization
Biological Processdecidualization
Biological Processdendrite development
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processgastric acid secretion
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of circadian sleep/wake cycle, REM sleep
Biological Processnegative regulation of endothelial cell proliferation
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of insulin secretion
Biological Processnegative regulation of interleukin-1 beta production
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of tumor necrosis factor production
Biological Processpositive regulation of adipose tissue development
Biological Processpositive regulation of appetite
Biological Processpositive regulation of bone development
Biological Processpositive regulation of circadian sleep/wake cycle, non-REM sleep
Biological Processpositive regulation of corticotropin secretion
Biological Processpositive regulation of cortisol secretion
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of eating behavior
Biological Processpositive regulation of gastric mucosal blood circulation
Biological Processpositive regulation of growth hormone secretion
Biological Processpositive regulation of growth rate
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of small intestinal transit
Biological Processpositive regulation of small intestine smooth muscle contraction
Biological Processpositive regulation of sprouting angiogenesis
Biological Processpositive regulation of synapse assembly
Biological Processpositive regulation of vascular endothelial cell proliferation
Biological Processpostsynaptic modulation of chemical synaptic transmission
Biological Processregulation of gastric motility
Biological Processregulation of postsynapse organization
Biological Processregulation of transmission of nerve impulse
Biological Processresponse to electrical stimulus
Biological Processresponse to estrogen

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Recommended name
    Appetite-regulating hormone
  • Alternative names
    • Growth hormone secretagogue
    • Growth hormone-releasing peptide
    • Motilin-related peptide
  • Cleaved into 2 chains

Gene names

    • Name
      Ghrl

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Swiss Webster
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A2RSS9

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_501429683324-117Appetite-regulating hormone

Post-translational modification

O-octanoylation is essential for ghrelin activity.

Keywords

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain24-51Motilin/ghrelin
Region28-69Disordered
Compositional bias33-47Basic and acidic residues
Compositional bias54-69Basic and acidic residues
Domain57-115Motilin/ghrelin-associated peptide

Sequence similarities

Belongs to the motilin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    117
  • Mass (Da)
    13,207
  • Last updated
    2007-03-06 v1
  • Checksum
    EACB49D2E3CA7203
MLSSGTICSLLLLSMLWMDMAMAGSSFLSPEHQKAQQRKESKKPPAKLQPRALEGWLHPEDRGQAEETEEELEIRFNAPFDVGIKLSGAQYQQHGRALGKFLQDILWEEVKEAPADK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias33-47Basic and acidic residues
Compositional bias54-69Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC132230
EMBL· GenBank· DDBJ
AAI32231.1
EMBL· GenBank· DDBJ
mRNA
BC132232
EMBL· GenBank· DDBJ
AAI32233.1
EMBL· GenBank· DDBJ
mRNA
FJ914266
EMBL· GenBank· DDBJ
ACR83863.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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