A2QFA7 · A2QFA7_ASPNC

Function

function

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site393Proton donor/acceptor

GO annotations

AspectTerm
Cellular ComponentNuA4 histone acetyltransferase complex
Cellular Componentpericentric heterochromatin
Cellular Componentsite of double-strand break
Cellular ComponentSwr1 complex
Molecular Functionhistone H3K4 acetyltransferase activity
Molecular Functionhistone H4K16 acetyltransferase activity
Molecular Functionpeptide butyryltransferase activity
Molecular Functiontranscription coregulator activity
Biological ProcessDNA repair
Biological ProcessDNA repair-dependent chromatin remodeling
Biological Processnegative regulation of DNA-templated transcription
Biological Processpositive regulation of heterochromatin formation
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone acetyltransferase
  • EC number

Gene names

    • ORF names
      An02g13870

Organism names

Accessions

  • Primary accession
    A2QFA7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Component of the NuA4 histone acetyltransferase complex.

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias80-97Basic and acidic residues
Region80-173Disordered
Compositional bias120-134Polar residues
Domain217-493MYST-type HAT
Region584-632Disordered

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    632
  • Mass (Da)
    72,726
  • Last updated
    2007-03-06 v1
  • Checksum
    09505FADFDA36FDC
MGGRDEATGTPDPVEKGFATLNTIRIGVKAMVQKDGELRKAEILSIKQRKDGPSFYVHYVDFNKRLDEWIDSGRIDLSHEVEWPQPEKPEKKKTGPGNKAPSKNAQKRARAESRDVSATPDLLTGKNTNVGKAQRPSKAGGKENRDETPVNLSIGGSEAVSADGTPKPDSDDVDMIDVGFSKDEKEEAKALGLMSREEEIERLRTSGSMTQNPTEIHRVRNLTRLQMGKYDIEPWYFSPYPASFSDADVVYIDEFCLGYFDNKRAFERHRSKCTLVHPPGNEIYRDDYISFFEVDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMCSRDETGCHLVGYFSKEKDSAEGYNLACILTLPQYQRRGYGRLLISFSYELGKREGKLGSPEKPLSDLGLLSYRQYWRETLVELLLETGRESVSEHDLSMLTSMTEKDVHETLVVFNMLRYHKGNWVIVLTDQVVEEHKKRLEKEKIKGVRKIDPARLQWKPPVFTASSRTWNCKVWDGSREAGKPGRLIDTLIWSRWCNLQLRLTEQHITLKYSNAHLSTKARYTVLHVNTKLPHHLPFPRILAPVPQAIEKKKEGDPMAQRRSPHRRDLGGQDSRKEGDSERRDMGWFRPPEKTEIKKH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias80-97Basic and acidic residues
Compositional bias120-134Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM270039
EMBL· GenBank· DDBJ
CAK37971.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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