A2QFA7 · A2QFA7_ASPNC
- ProteinHistone acetyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids632 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.
Catalytic activity
- (2E)-butenoyl-CoA + L-lysyl-[protein] = N6-(2E)-butenoyl-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
- 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
- L-lysyl-[protein] + acetyl-CoA = N6-acetyl-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 393 | Proton donor/acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | NuA4 histone acetyltransferase complex | |
Cellular Component | pericentric heterochromatin | |
Cellular Component | site of double-strand break | |
Cellular Component | Swr1 complex | |
Molecular Function | histone H3K4 acetyltransferase activity | |
Molecular Function | histone H4K16 acetyltransferase activity | |
Molecular Function | peptide butyryltransferase activity | |
Molecular Function | transcription coregulator activity | |
Biological Process | DNA repair | |
Biological Process | DNA repair-dependent chromatin remodeling | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | positive regulation of heterochromatin formation | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone acetyltransferase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionA2QFA7
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Component of the NuA4 histone acetyltransferase complex.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 80-97 | Basic and acidic residues | |||
Region | 80-173 | Disordered | |||
Compositional bias | 120-134 | Polar residues | |||
Domain | 217-493 | MYST-type HAT | |||
Region | 584-632 | Disordered | |||
Sequence similarities
Belongs to the MYST (SAS/MOZ) family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length632
- Mass (Da)72,726
- Last updated2007-03-06 v1
- Checksum09505FADFDA36FDC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 80-97 | Basic and acidic residues | |||
Compositional bias | 120-134 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM270039 EMBL· GenBank· DDBJ | CAK37971.1 EMBL· GenBank· DDBJ | Genomic DNA |