A2PZ70 · A2PZ70_CRYJA
- ProteinS-adenosylmethionine synthase
- GeneCC2188
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids316 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Catalytic activity
- L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Co2+ (UniProtKB | Rhea| CHEBI:48828 )
Note: Binds 2 divalent ions per subunit. The metal ions interact primarily with the substrate. Can utilize magnesium, manganese or cobalt (in vitro).
Pathway
Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | methionine adenosyltransferase activity | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameS-adenosylmethionine synthase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Pinopsida > Pinidae > Conifers II > Cupressales > Cupressaceae > Cryptomeria
Accessions
- Primary accessionA2PZ70
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-170 | S-adenosylmethionine synthetase central | ||||
Sequence: IGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTDVRKNGTCPWLRPDGKTQVTIEYKNEKGAMVPLRVHTVLISTQHDETVTNDQIAADLKEHVIKPVIPAKYMDENTIFHLNPSGRF | ||||||
Domain | 172-313 | S-adenosylmethionine synthetase C-terminal | ||||
Sequence: IGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVAAGLARRCIVQVSYAIGVPEPLSVFVDSYGTGKIPDKEILNIIKTSFDFRPGMISINLDLKRGGNGRFQKTAAYGHFGRDDPDFTWE |
Sequence similarities
Belongs to the AdoMet synthase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length316
- Mass (Da)34,426
- Last updated2007-03-06 v1
- Checksum7D4A34726149791F
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Non-terminal residue | 316 | |||||
Sequence: K |