A2PZ70 · A2PZ70_CRYJA

Function

function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 2 divalent ions per subunit. The metal ions interact primarily with the substrate. Can utilize magnesium, manganese or cobalt (in vitro).

Pathway

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionmethionine adenosyltransferase activity
Biological Processone-carbon metabolic process
Biological ProcessS-adenosylmethionine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosylmethionine synthase
  • EC number

Gene names

    • Name
      CC2188

Organism names

Accessions

  • Primary accession
    A2PZ70

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-170S-adenosylmethionine synthetase central
Domain172-313S-adenosylmethionine synthetase C-terminal

Sequence similarities

Belongs to the AdoMet synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    316
  • Mass (Da)
    34,426
  • Last updated
    2007-03-06 v1
  • Checksum
    7D4A34726149791F
VRKTCREIGFISDDVGLDADKCRVLVNIEQQSPDIAQGVHGHLTKRPEDIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTDVRKNGTCPWLRPDGKTQVTIEYKNEKGAMVPLRVHTVLISTQHDETVTNDQIAADLKEHVIKPVIPAKYMDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVAAGLARRCIVQVSYAIGVPEPLSVFVDSYGTGKIPDKEILNIIKTSFDFRPGMISINLDLKRGGNGRFQKTAAYGHFGRDDPDFTWEIVK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue316

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB264254
EMBL· GenBank· DDBJ
BAF46024.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp