A2CG49 · KALRN_MOUSE
- ProteinKalirin
- GeneKalrn
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids2964 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKalirin
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA2CG49
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000308173 | 1-2964 | Kalirin | |||
Sequence: MVLSGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQHALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQSLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEVLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPTEARDSAMSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGIELICEKDLDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIEKTHQSALQVQQKAEALLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGEYYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEINEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPAKLRNNSKRDGVEDGDSQGDGSSQPDTISIASRTSQNTVESDKLSGGCELTVVLQDFSAGHSSELSIQVGQTVELLERPSERPGWCLVRTTERSPPQEGLVPSSALCISHSRSSVEMDCFFPLKDSYSHSSSENGGKSESVAHLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSLLAARQAPPDVPTAADLVSAIEKLVKNKLTLEGGSYRGSLKDPTGCLNEGMTPPTPPRNLEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEDNVDGDPCKFALMNRETSERVILQAANSDIQQAWVQDINQVLETQRDFLNALQSPIEYQRKERSTAVIRSQPPRVPQASPRPYSSGPVGSEKPPKGSSYNPPLPPLKISTSNGSPGFDYHQPGDKFDASKQNDLGGCNGTSTMTVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLAKATAAAESSDGSIKKSCSWHTLRMRKRADVENSGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVLLQCKACGRPKPSITWKGPDQNILDTDNSSATYTISSCDSGESTLKICNLMPQDSGIYTCIAANDHGTASTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPASTGNCTISGYTVEYREEGSQVWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGTSLSHNP | ||||||
Modified residue | 1722 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1725 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1771 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1784 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1789 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1881 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1884 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 2233 | Phosphoserine | ||||
Sequence: S | ||||||
Disulfide bond | 2464↔2520 | |||||
Sequence: CKACGRPKPSITWKGPDQNILDTDNSSATYTISSCDSGESTLKICNLMPQDSGIYTC |
Post-translational modification
Autophosphorylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-162 | CRAL-TRIO | ||||
Sequence: VLPILKEKVAFVSGGRDKRGGPILTFPARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFPAEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH | ||||||
Repeat | 149-290 | Spectrin 1 | ||||
Sequence: QLTEEFDGSLDYNHEEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWHVRKLKLDQ | ||||||
Repeat | 292-399 | Spectrin 2 | ||||
Sequence: FQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQHALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMS | ||||||
Repeat | 400-517 | Spectrin 3 | ||||
Sequence: AVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQSLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQR | ||||||
Repeat | 518-621 | Spectrin 4 | ||||
Sequence: LQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLL | ||||||
Repeat | 622-752 | Spectrin 5 | ||||
Sequence: LDMSVSFHTHTKELWTWMEDLQKEVLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPTEARDSAMSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQ | ||||||
Region | 692-717 | Disordered | ||||
Sequence: SAPPSLGEPTEARDSAMSNNKTPHSS | ||||||
Compositional bias | 703-717 | Polar residues | ||||
Sequence: ARDSAMSNNKTPHSS | ||||||
Repeat | 753-870 | Spectrin 6 | ||||
Sequence: LRIFEQYTIEVTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGIELICEKDLDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQ | ||||||
Repeat | 871-977 | Spectrin 7 | ||||
Sequence: CLQLRHLQAEVKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIEKTHQSALQVQQKAEALLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNA | ||||||
Repeat | 978-1101 | Spectrin 8 | ||||
Sequence: SVAFYKTSEQVCSVLESLEQEYRRDEDWCGGRDKLGPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQ | ||||||
Repeat | 1102-1207 | Spectrin 9 | ||||
Sequence: CQQYVVFERSAKQALDWIQETGEYYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSL | ||||||
Domain | 1254-1429 | DH 1 | ||||
Sequence: KKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRVTKYQLLLKELLTCCEEGKGELKDGLEVMLSVPKKANDA | ||||||
Domain | 1441-1553 | PH 1 | ||||
Sequence: NLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQ | ||||||
Region | 1568-1615 | Disordered | ||||
Sequence: QLPKTPAKLRNNSKRDGVEDGDSQGDGSSQPDTISIASRTSQNTVESD | ||||||
Compositional bias | 1590-1615 | Polar residues | ||||
Sequence: SQGDGSSQPDTISIASRTSQNTVESD | ||||||
Domain | 1619-1684 | SH3 1 | ||||
Sequence: GGCELTVVLQDFSAGHSSELSIQVGQTVELLERPSERPGWCLVRTTERSPPQEGLVPSSALCISHS | ||||||
Compositional bias | 1700-1745 | Polar residues | ||||
Sequence: YSHSSSENGGKSESVAHLQSQPSLNSIHSSPGPKRSTNTLKKWLTS | ||||||
Region | 1700-1825 | Disordered | ||||
Sequence: YSHSSSENGGKSESVAHLQSQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQD | ||||||
Compositional bias | 1754-1776 | Basic and acidic residues | ||||
Sequence: KADGNIKKQKKVRDGRKSFDLGS | ||||||
Compositional bias | 1785-1809 | Basic and acidic residues | ||||
Sequence: PQGDSADEKSKKGWGEDEPDEESHT | ||||||
Region | 1869-1888 | Disordered | ||||
Sequence: LKDPTGCLNEGMTPPTPPRN | ||||||
Domain | 1900-2075 | DH 2 | ||||
Sequence: GRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKEKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCNDM | ||||||
Domain | 2087-2197 | PH 2 | ||||
Sequence: TLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEDNVDGDPCKFALMNRETSERVILQAANSDIQQAWVQDINQVLE | ||||||
Region | 2215-2285 | Disordered | ||||
Sequence: KERSTAVIRSQPPRVPQASPRPYSSGPVGSEKPPKGSSYNPPLPPLKISTSNGSPGFDYHQPGDKFDASKQ | ||||||
Compositional bias | 2257-2271 | Polar residues | ||||
Sequence: LPPLKISTSNGSPGF | ||||||
Domain | 2292-2357 | SH3 2 | ||||
Sequence: NGTSTMTVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLAK | ||||||
Compositional bias | 2384-2406 | Basic and acidic residues | ||||
Sequence: ADVENSGKNEATGPRKPKDILGN | ||||||
Region | 2384-2426 | Disordered | ||||
Sequence: ADVENSGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDP | ||||||
Domain | 2443-2536 | Ig-like C2-type | ||||
Sequence: PEFLVPLVDVTCLLGDTVLLQCKACGRPKPSITWKGPDQNILDTDNSSATYTISSCDSGESTLKICNLMPQDSGIYTCIAANDHGTASTSATVK | ||||||
Domain | 2543-2637 | Fibronectin type-III | ||||
Sequence: APNRPIAQERSCTSVILRWLPPASTGNCTISGYTVEYREEGSQVWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEY | ||||||
Domain | 2656-2910 | Protein kinase | ||||
Sequence: YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWL |
Domain
The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 10 isoforms produced by Alternative splicing & Alternative initiation.
A2CG49-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsKalirin-12A
- NoteProduced by alternative splicing.
- Length2,964
- Mass (Da)337,000
- Last updated2007-02-20 v1
- Checksum76064FE06AA2BD9C
A2CG49-2
- Name2
- SynonymsKalirin-9A
- NoteProduced by alternative splicing.
- Differences from canonical
- 2371-2375: KSCSW → TLLKP
- 2376-2964: Missing
A2CG49-3
- Name3
- NoteProduced by alternative splicing.
- Differences from canonical
- 1-2731: Missing
A2CG49-4
- Name4
- NoteProduced by alternative splicing.
- Differences from canonical
- 1-1669: Missing
- 1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
- 1828-1858: Missing
- 2285-2285: Missing
- 2372-2374: SCS → EPY
- 2375-2964: Missing
A2CG49-5
- Name5
- NoteProduced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.
- Differences from canonical
- 1-623: Missing
- 923-923: E → ESLFHATSLQ
- 1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
- 1637-2964: Missing
A2CG49-6
- Name6
- NoteProduced by alternative splicing.
- Differences from canonical
- 1-1669: Missing
- 1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
- 2285-2285: Missing
- 2357-2364: KATAAAES → QSQSRGRK
- 2365-2964: Missing
A2CG49-7
- Name7
- NoteProduced by alternative splicing.
- Differences from canonical
- 1-4: MVLS → MNPPEGASEEGGAADSDVDAFFRT
- 1859-1898: TLEGGSYRGSLKDPTGCLNEGMTPPTPPRNLEEEQKAKAL → VSGHAGGSSELPLTSVWLPGPQPGPRTGLPHPNFTNRNCI
A2CG49-8
- Name8
- NoteProduced by alternative splicing.
- Differences from canonical
- 1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
- 923-923: E → ESLFHATSLQ
- 1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
- 1637-2964: Missing
A2CG49-9
- Name9
- SynonymsKalirin-7c
- NoteProduced by alternative splicing.
- Differences from canonical
- 1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
- 1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
- 1637-2964: Missing
A2CG49-10
- Name10
- SynonymsDelta Kalirin-7
- Differences from canonical
- 1-623: Missing
- 1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
- 1637-2964: Missing
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_052565 | 1-4 | in isoform 7 | |||
Sequence: MVLS → MNPPEGASEEGGAADSDVDAFFRT | ||||||
Alternative sequence | VSP_052566 | 1-4 | in isoform 8 and isoform 9 | |||
Sequence: MVLS → MTDRFWDQWYLWYLRLLRLLDR | ||||||
Alternative sequence | VSP_052564 | 1-623 | in isoform 5 and isoform 10 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052563 | 1-1669 | in isoform 4 and isoform 6 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052562 | 1-2731 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 703-717 | Polar residues | ||||
Sequence: ARDSAMSNNKTPHSS | ||||||
Sequence conflict | 711 | In A2CG49; in Ref. 1; BAE34776 | ||||
Sequence: E → K | ||||||
Alternative sequence | VSP_052567 | 923 | in isoform 5 and isoform 8 | |||
Sequence: E → ESLFHATSLQ | ||||||
Compositional bias | 1590-1615 | Polar residues | ||||
Sequence: SQGDGSSQPDTISIASRTSQNTVESD | ||||||
Alternative sequence | VSP_052568 | 1617-1636 | in isoform 5, isoform 8, isoform 9 and isoform 10 | |||
Sequence: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV | ||||||
Alternative sequence | VSP_052569 | 1637-2964 | in isoform 5, isoform 8, isoform 9 and isoform 10 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052570 | 1670-1697 | in isoform 4 and isoform 6 | |||
Sequence: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR | ||||||
Compositional bias | 1700-1745 | Polar residues | ||||
Sequence: YSHSSSENGGKSESVAHLQSQPSLNSIHSSPGPKRSTNTLKKWLTS | ||||||
Compositional bias | 1754-1776 | Basic and acidic residues | ||||
Sequence: KADGNIKKQKKVRDGRKSFDLGS | ||||||
Compositional bias | 1785-1809 | Basic and acidic residues | ||||
Sequence: PQGDSADEKSKKGWGEDEPDEESHT | ||||||
Sequence conflict | 1824 | in Ref. 1; BAC40535 | ||||
Sequence: Q → H | ||||||
Alternative sequence | VSP_052571 | 1828-1858 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052572 | 1859-1898 | in isoform 7 | |||
Sequence: TLEGGSYRGSLKDPTGCLNEGMTPPTPPRNLEEEQKAKAL → VSGHAGGSSELPLTSVWLPGPQPGPRTGLPHPNFTNRNCI | ||||||
Compositional bias | 2257-2271 | Polar residues | ||||
Sequence: LPPLKISTSNGSPGF | ||||||
Alternative sequence | VSP_052573 | 2285 | in isoform 4 and isoform 6 | |||
Sequence: Missing | ||||||
Sequence conflict | 2316 | in Ref. 1; BAB25925 | ||||
Sequence: G → S | ||||||
Sequence conflict | 2344 | in Ref. 1; BAB25925 | ||||
Sequence: E → K | ||||||
Sequence conflict | 2355 | in Ref. 1; BAB25925 | ||||
Sequence: L → F | ||||||
Alternative sequence | VSP_052574 | 2357-2364 | in isoform 6 | |||
Sequence: KATAAAES → QSQSRGRK | ||||||
Alternative sequence | VSP_052575 | 2365-2964 | in isoform 6 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052576 | 2371-2375 | in isoform 2 | |||
Sequence: KSCSW → TLLKP | ||||||
Alternative sequence | VSP_052577 | 2372-2374 | in isoform 4 | |||
Sequence: SCS → EPY | ||||||
Alternative sequence | VSP_052578 | 2375-2964 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052579 | 2376-2964 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 2384-2406 | Basic and acidic residues | ||||
Sequence: ADVENSGKNEATGPRKPKDILGN |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK008844 EMBL· GenBank· DDBJ | BAB25925.1 EMBL· GenBank· DDBJ | mRNA | ||
AK081504 EMBL· GenBank· DDBJ | BAC38239.1 EMBL· GenBank· DDBJ | mRNA | ||
AK088732 EMBL· GenBank· DDBJ | BAC40535.1 EMBL· GenBank· DDBJ | mRNA | ||
AK139581 EMBL· GenBank· DDBJ | BAE24075.1 EMBL· GenBank· DDBJ | mRNA | ||
AK158544 EMBL· GenBank· DDBJ | BAE34552.1 EMBL· GenBank· DDBJ | mRNA | ||
AK159031 EMBL· GenBank· DDBJ | BAE34776.1 EMBL· GenBank· DDBJ | mRNA | ||
CT010573 EMBL· GenBank· DDBJ | CAM18305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154524 EMBL· GenBank· DDBJ | CAM18305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC155257 EMBL· GenBank· DDBJ | CAM18305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC165079 EMBL· GenBank· DDBJ | CAM18305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CT010573 EMBL· GenBank· DDBJ | CAM18306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154524 EMBL· GenBank· DDBJ | CAM18306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC165079 EMBL· GenBank· DDBJ | CAM18306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CT010573 EMBL· GenBank· DDBJ | CAM18307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154524 EMBL· GenBank· DDBJ | CAM18307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154588 EMBL· GenBank· DDBJ | CAM18307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CT010573 EMBL· GenBank· DDBJ | CAM18308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154524 EMBL· GenBank· DDBJ | CAM18308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154588 EMBL· GenBank· DDBJ | CAM18308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CT010573 EMBL· GenBank· DDBJ | CAM18309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154524 EMBL· GenBank· DDBJ | CAM18309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC154588 EMBL· GenBank· DDBJ | CAM18309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC157950 EMBL· GenBank· DDBJ | AAI57951.1 EMBL· GenBank· DDBJ | mRNA | ||
BC172101 EMBL· GenBank· DDBJ | AAI72101.1 EMBL· GenBank· DDBJ | mRNA |