A2CEE6 · A2CEE6_MOUSE
- ProteinRibosomal protein S6 kinase
- GeneRps6ka6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids720 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 99-107 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGQGSFGKV | ||||||
Binding site | 125 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 218 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 452-460 | ATP (UniProtKB | ChEBI) | ||||
Sequence: IGIGSYSVC | ||||||
Binding site | 475 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 563 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal protein S6 kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA2CEE6
Proteomes
Organism-specific databases
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 93-350 | Protein kinase | ||||
Sequence: FDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEVKRHAFF | ||||||
Domain | 351-420 | AGC-kinase C-terminal | ||||
Sequence: ASIDWNKLYKREVQPPFRPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYK | ||||||
Domain | 446-706 | Protein kinase | ||||
Sequence: YELKEDIGIGSYSVCKRCIHSASNVEFAVKIIDKNKRDPSEEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKEAVAAPYSVLARNPNRHHPILEPVTASRL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length720
- Mass (Da)81,253
- Last updated2022-12-14 v2
- ChecksumF55A3CBC864289CF
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q7TPS0 | KS6A6_MOUSE | Rps6ka6 | 764 | ||
E9PUP0 | E9PUP0_MOUSE | Rps6ka6 | 759 | ||
A2CEE5 | A2CEE5_MOUSE | Rps6ka6 | 743 | ||
A2CEE7 | A2CEE7_MOUSE | Rps6ka6 | 764 | ||
A2CEE8 | A2CEE8_MOUSE | Rps6ka6 | 146 | ||
B1B0X1 | B1B0X1_MOUSE | Rps6ka6 | 203 | ||
B1B0X2 | B1B0X2_MOUSE | Rps6ka6 | 166 | ||
B1B0X3 | B1B0X3_MOUSE | Rps6ka6 | 860 | ||
B1B0X4 | B1B0X4_MOUSE | Rps6ka6 | 130 | ||
B2GVN8 | B2GVN8_MOUSE | Rps6ka6 | 162 |
Keywords
- Technical term