A2C6V3 · A2C6V3_PROM3

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • Ordered locus names
      P9303_04611

Organism names

Accessions

  • Primary accession
    A2C6V3

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane38-56Helical
Transmembrane76-94Helical
Transmembrane101-123Helical
Transmembrane135-156Helical
Transmembrane163-184Helical
Transmembrane190-211Helical
Transmembrane251-274Helical
Transmembrane286-306Helical
Transmembrane318-336Helical
Transmembrane342-367Helical
Transmembrane379-405Helical
Transmembrane417-437Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-451Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    451
  • Mass (Da)
    48,905
  • Last updated
    2007-02-20 v1
  • Checksum
    07F534D099F54674
MTSNPGESRSIQSQSSAQQRISNLHGQAQRARRGWRPWILFLVCSLFYFYEFFARVAPGVLQPELMRVTGSSQGEFGLAMGMYFLAYAPSQLLVGRLLDRFGVRAVVAPAALVVALGCLLFASTNNVVVLGLGRLMQGLGSSVAYLGVIYLAMIWFPPKRHGMVPGLTVAMGTLGASFAQYPLLILTKSWGWRVPLLVCTGAGLVIALMLWKLLPKRPNWFVELMREDGFDPKSPQPLASLIKEIMRDRNIWCLSLAAAGLYLPISVIGDLWGVTFLHIHSGLSTGLSSLLTTLIFIGFAAGGIATGHLSDHLKRRKILFVTGAILSSVIAVAIALTNSAPLWWNAMLMIALGLTTGSQLLAFVMTADVAKRHNRAVKLAFVNFVVMVLPVFIQPAVGFLAQIGVAKGLVPSPGQELQGYGLVVVLMFISTGLSLCVKDTKPRKEKFVIAH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000554
EMBL· GenBank· DDBJ
ABM77213.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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