A2C604 · A2C604_PROM3

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site87Na+ (UniProtKB | ChEBI); structural
Binding site90Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • Ordered locus names
      P9303_01591

Organism names

Accessions

  • Primary accession
    A2C604

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane45-65Helical
Transmembrane77-100Helical
Transmembrane112-133Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    135
  • Mass (Da)
    13,803
  • Last updated
    2007-02-20 v1
  • Checksum
    3E9CE0E61D1D9A5C
MAGSMSDLALPAWQASLVAIGAVPGAWLRLRVVNHLEPMVPRKHWGTFAVNMVAAFALGLVLALQAKCAPASGASPLILLIGVGFFGSLSTFSTFAGEVLNTLREHRWSEALVLAVGSILGGLLAVAAGVGLADG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000554
EMBL· GenBank· DDBJ
ABM76914.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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