A2C247 · COAD_PROM1

Function

function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site8substrate
Binding site8-9ATP (UniProtKB | ChEBI)
Binding site16ATP (UniProtKB | ChEBI)
Site16Transition state stabilizer
Binding site40substrate
Binding site72substrate
Binding site86substrate
Binding site87-89ATP (UniProtKB | ChEBI)
Binding site97ATP (UniProtKB | ChEBI)
Binding site122-128ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionpantetheine-phosphate adenylyltransferase activity
Biological Processcoenzyme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphopantetheine adenylyltransferase
  • EC number
  • Alternative names
    • Dephospho-CoA pyrophosphorylase
    • Pantetheine-phosphate adenylyltransferase
      (PPAT
      )

Gene names

    • Name
      coaD
    • Ordered locus names
      NATL1_09991

Organism names

Accessions

  • Primary accession
    A2C247

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000111981-158Phosphopantetheine adenylyltransferase

Interaction

Subunit

Homohexamer.

Structure

Family & Domains

Sequence similarities

Belongs to the bacterial CoaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    158
  • Mass (Da)
    17,806
  • Last updated
    2007-02-20 v1
  • Checksum
    DC6031A167692544
MKALYPGSFDPLTFGHLDLIQRGSDLFGEVLIAVLENPSKKATFSCKRRIEQIENATKDIPGCRTIAFKGLTVDCARENNADLILRGLRAMSDFEYELQVAHTNRSLNNQYETIFLATETHHSFLSSSVVKEVARFGGEIRHMVPEFIAKDLMKLNTN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000553
EMBL· GenBank· DDBJ
ABM75557.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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