A2C247 · COAD_PROM1
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids158 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 8 | substrate | ||||
Sequence: S | ||||||
Binding site | 8-9 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SF | ||||||
Binding site | 16 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 16 | Transition state stabilizer | ||||
Sequence: H | ||||||
Binding site | 40 | substrate | ||||
Sequence: K | ||||||
Binding site | 72 | substrate | ||||
Sequence: T | ||||||
Binding site | 86 | substrate | ||||
Sequence: R | ||||||
Binding site | 87-89 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLR | ||||||
Binding site | 97 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 122-128 | ATP (UniProtKB | ChEBI) | ||||
Sequence: HSFLSSS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Prochlorococcaceae > Prochlorococcus
Accessions
- Primary accessionA2C247
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000011198 | 1-158 | Phosphopantetheine adenylyltransferase | |||
Sequence: MKALYPGSFDPLTFGHLDLIQRGSDLFGEVLIAVLENPSKKATFSCKRRIEQIENATKDIPGCRTIAFKGLTVDCARENNADLILRGLRAMSDFEYELQVAHTNRSLNNQYETIFLATETHHSFLSSSVVKEVARFGGEIRHMVPEFIAKDLMKLNTN |
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length158
- Mass (Da)17,806
- Last updated2007-02-20 v1
- ChecksumDC6031A167692544
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000553 EMBL· GenBank· DDBJ | ABM75557.1 EMBL· GenBank· DDBJ | Genomic DNA |