A2BK45 · A2BK45_HYPBU

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site255Mn2+ 2 (UniProtKB | ChEBI)
Binding site260Mn2+ 1 (UniProtKB | ChEBI)
Binding site260Mn2+ 2 (UniProtKB | ChEBI)
Active site267
Binding site278Mn2+ 2 (UniProtKB | ChEBI)
Binding site337Mn2+ 1 (UniProtKB | ChEBI)
Binding site339Mn2+ 2 (UniProtKB | ChEBI)
Binding site339Mn2+ 1 (UniProtKB | ChEBI)
Active site341

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • Ordered locus names
      Hbut_0494

Organism names

Accessions

  • Primary accession
    A2BK45

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain335-342Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    52,933
  • Last updated
    2007-02-20 v1
  • Checksum
    8A7F4908922FD8B6
MSTLLRVGNARNGVDAIAYVAGEKQLEWLKGFGDTVRTVIELGDFKGKLEETILIYESSATVKRVILAGAGGNEWFGDAERLRVAVASAVKLARSKKSIKRLGVVVHEELLEKAAETAGRDTVWSVEQALVAADMANYVYSLREREEKPHILEEVRLEPGDEKAVETAKAIAEAVRVARDIANAPANRLSPEKLEEKARELASRLGLTIRVLYRSDLESLGMGGILAVGSGSNVEPRLIILEYNSGGKRIAVVGKAVVFDAGGLDLKPPQAMQEMKFDKSGGAAAIGAVVAAALLRLPVNMVALVPAVENLPSGRAYKPLDVIRMYNGTTVEIGNTDAEGRLIMADALAYAAEKYKPDYMFDFATLTGAAVVALGNHAAALFSNNDQLASMVERAAWIAGEPVWKMPLWPVYAKQLESHVADTNNVGGRPAGAITAAKFLEKFVGDRPWAHLDIAGTAWVQEKGPWKPYYEKGATGWGVRTLVEFLRLLI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000493
EMBL· GenBank· DDBJ
ABM80356.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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