A2BK45 · A2BK45_HYPBU
- ProteinProbable cytosol aminopeptidase
- GenepepA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids490 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Catalytic activity
- Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
Cofactor
Note: Binds 2 manganese ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 255 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 260 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 260 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 267 | |||||
Sequence: K | ||||||
Binding site | 278 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 337 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 339 | Mn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 339 | Mn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 341 | |||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | manganese ion binding | |
Molecular Function | metalloaminopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable cytosol aminopeptidase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Desulfurococcales > Pyrodictiaceae > Hyperthermus
Accessions
- Primary accessionA2BK45
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 335-342 | Cytosol aminopeptidase | ||||
Sequence: NTDAEGRL |
Sequence similarities
Belongs to the peptidase M17 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length490
- Mass (Da)52,933
- Last updated2007-02-20 v1
- Checksum8A7F4908922FD8B6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000493 EMBL· GenBank· DDBJ | ABM80356.1 EMBL· GenBank· DDBJ | Genomic DNA |